Simulation scenario 5, CR phase

Setting description

Taxel therapies more effective in the TEfus+ biomarker signature

Simulations setting

Survival curves (by signature)

PFS distributions (by signature)

Treatment effects (by signature)

signature	var	Other	Hormone_therapies	Taxel_therapies	Carboplatin	Niraparib
all	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.084, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 11.6, median = 8.4	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1.32, hr = 0.75	af = 1, hr = 1	af = 1, hr = 1
TP53- & AR-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.093, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 10.5, median = 7.6	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1.2, hr = 0.83	af = 1, hr = 1	af = 1, hr = 1
TP53+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.079, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 12.4, median = 8.9	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1.42, hr = 0.69	af = 1, hr = 1	af = 1, hr = 1
DRD+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.075, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 13.1, median = 9.4	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1.49, hr = 0.66	af = 1, hr = 1	af = 1, hr = 1
TEfus+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 26.6, median = 19.1	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 3.03, hr = 0.31	af = 1, hr = 1	af = 1, hr = 1

Survival curves (by subgroup)

PFS distributions (by subgroup)

Treatment effects (by subgroup)

subtype	var	Other	Hormone_therapies	Taxel_therapies	Carboplatin	Niraparib
—-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
—+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 26.6, median = 19.1	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 3.03, hr = 0.31	af = 1, hr = 1	af = 1, hr = 1
–+-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
–++	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 26.6, median = 19.1	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 3.03, hr = 0.31	af = 1, hr = 1	af = 1, hr = 1
-+–	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
-+-+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 26.6, median = 19.1	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 3.03, hr = 0.31	af = 1, hr = 1	af = 1, hr = 1
-++-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
-+++	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 26.6, median = 19.1	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 3.03, hr = 0.31	af = 1, hr = 1	af = 1, hr = 1
+—	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+–+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 26.6, median = 19.1	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 3.03, hr = 0.31	af = 1, hr = 1	af = 1, hr = 1
+-+-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+-++	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 26.6, median = 19.1	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 3.03, hr = 0.31	af = 1, hr = 1	af = 1, hr = 1
++–	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
++-+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 26.6, median = 19.1	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 3.03, hr = 0.31	af = 1, hr = 1	af = 1, hr = 1
+++-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
++++	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 26.6, median = 19.1	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 3.03, hr = 0.31	af = 1, hr = 1	af = 1, hr = 1

Errors and power

graduation (counts and proportions):

Hormone_therapies Taxel_therapies Carboplatin Niraparib all 4 20 1 0 TP53- & AR- 30 115 9 6 TP53+ 4 36 3 1 DRD+ 0 32 0 0 TEfus+ 1 325 0 0

Hormone_therapies Taxel_therapies Carboplatin Niraparib all 0.008 0.040 0.002 0.000 TP53- & AR- 0.060 0.230 0.018 0.012 TP53+ 0.008 0.072 0.006 0.002 DRD+ 0.000 0.064 0.000 0.000 TEfus+ 0.002 0.650 0.000 0.000

futility (counts and proportions):

Hormone_therapies Taxel_therapies Carboplatin Niraparib all 15 0 6 4 TP53- & AR- 244 6 221 208 TP53+ 74 1 79 77 DRD+ 41 2 81 67 TEfus+ 218 0 239 227

Hormone_therapies Taxel_therapies Carboplatin Niraparib all 0.030 0.000 0.012 0.008 TP53- & AR- 0.488 0.012 0.442 0.416 TP53+ 0.148 0.002 0.158 0.154 DRD+ 0.082 0.004 0.162 0.134 TEfus+ 0.436 0.000 0.478 0.454

max sample size (counts and proportions):

Hormone_therapies Taxel_therapies Carboplatin Niraparib all 0 0 0 0 TP53- & AR- 16 16 12 13 TP53+ 6 31 2 22 DRD+ 0 0 0 0 TEfus+ 0 21 3 2

Hormone_therapies Taxel_therapies Carboplatin Niraparib all 0.000 0.000 0.000 0.000 TP53- & AR- 0.032 0.032 0.024 0.026 TP53+ 0.012 0.062 0.004 0.044 DRD+ 0.000 0.000 0.000 0.000 TEfus+ 0.000 0.042 0.006 0.004

Errors & power

The overall error was 0.228.
The corresponding errors separate for the different treatments were:

Hormone_therapies   Taxel_therapies       Carboplatin         Niraparib 
            0.078             0.124             0.026             0.014 

The overall power was 0.65.
The corresponding power separate for the different treatments were:

Hormone_therapies   Taxel_therapies       Carboplatin         Niraparib 
             0.00              0.65              0.00              0.00 

Median results at the end of the trial

By signature:

signature	var	Control	Hormone_therapies	Taxel_therapies	Carboplatin	Niraparib
all	graduation	0	4	20	1	0
	futility	0	15	0	6	4
	max_n	0	0	0	0	0
	n	422 (388, 454)	174 (115, 245)	189 (114, 275)	174 (120, 247)	180 (119, 255)
	n_unique	388 (359, 418)	160 (105, 228)	174 (104, 257)	158 (109, 228)	164 (110, 241)
	time_trial	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)
	time_stop	NA (NA, NA)	5 (3, 31)	6 (5, 23)	22 (7, 34)	28 (22, 30)
	post_p	NA (NA, NA)	0.06 (0, 0.39)	1 (0.95, 1)	0.07 (0, 0.37)	0.07 (0, 0.37)
	rate	0.096 (0.089, 0.104)	0.112 (0.102, 0.129)	0.067 (0.057, 0.081)	0.113 (0.102, 0.128)	0.112 (0.101, 0.127)
TP53- & AR-	graduation	0	30	115	9	6
	futility	0	244	6	221	208
	max_n	0	16	16	12	13
	n	174 (149, 198)	62 (27, 129)	64 (27, 121)	65 (27, 121)	66 (27, 129)
	n_unique	161 (137, 183)	56 (25, 121)	57 (25, 114)	60 (25, 114)	61 (26, 121)
	time_trial	36 (36, 36)	32 (10, 36)	36 (13, 36)	36 (16, 36)	36 (16, 36)
	time_stop	NA (NA, NA)	17 (8, 31)	15 (10, 29)	21 (13, 32)	21 (13, 33)
	post_p	NA (NA, NA)	0.24 (0.03, 0.7)	0.94 (0.55, 1)	0.24 (0.03, 0.68)	0.24 (0.04, 0.73)
	rate	0.101 (0.091, 0.113)	0.115 (0.097, 0.145)	0.078 (0.058, 0.099)	0.115 (0.098, 0.146)	0.113 (0.095, 0.144)
TP53+	graduation	0	4	36	3	1
	futility	0	74	1	79	77
	max_n	0	6	31	2	22
	n	188 (166, 210)	80 (45, 120)	92 (45, 139)	78 (43, 115)	80 (46, 124)
	n_unique	173 (152, 194)	73 (40, 112)	85 (40, 130)	71 (38, 107)	73 (42, 114)
	time_trial	36 (36, 36)	36 (29, 36)	36 (36, 36)	36 (25, 36)	36 (27, 36)
	time_stop	NA (NA, NA)	24 (13, 33)	14 (9, 27)	22 (13, 32)	23 (13, 34)
	post_p	NA (NA, NA)	0.11 (0.01, 0.56)	1 (0.85, 1)	0.1 (0.01, 0.47)	0.11 (0.01, 0.47)
	rate	0.093 (0.083, 0.104)	0.113 (0.097, 0.135)	0.061 (0.048, 0.078)	0.114 (0.097, 0.138)	0.113 (0.097, 0.135)
DRD+	graduation	0	0	32	0	0
	futility	0	41	2	81	67
	max_n	0	0	0	0	0
	n	113 (98, 130)	48 (26, 71)	46 (25, 78)	56 (34, 80)	58 (35, 82)
	n_unique	103 (89, 119)	44 (23, 64)	41 (22, 72)	51 (32, 73)	53 (33, 76)
	time_trial	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (24, 36)	36 (28, 36)
	time_stop	NA (NA, NA)	28 (19, 35)	20 (16, 30)	22 (14, 31)	20 (14, 32)
	post_p	NA (NA, NA)	0.19 (0.02, 0.58)	0.96 (0.61, 1)	0.14 (0.01, 0.53)	0.14 (0.02, 0.55)
	rate	0.092 (0.079, 0.107)	0.112 (0.092, 0.143)	0.064 (0.045, 0.086)	0.114 (0.096, 0.142)	0.113 (0.094, 0.138)
TEfus+	graduation	0	1	325	0	0
	futility	0	218	0	239	227
	max_n	0	0	21	3	2
	n	159 (139, 179)	55 (27, 93)	82 (28, 138)	58 (31, 98)	58 (34, 104)
	n_unique	146 (126, 164)	49 (25, 86)	76 (26, 128)	52 (28, 91)	53 (31, 96)
	time_trial	36 (36, 36)	36 (19, 36)	26 (11, 36)	36 (18, 36)	36 (19, 36)
	time_stop	NA (NA, NA)	25 (16, 35)	18 (10, 31)	26 (16, 34)	26 (17, 35)
	post_p	NA (NA, NA)	0.02 (0, 0.19)	1 (1, 1)	0.01 (0, 0.12)	0.01 (0, 0.13)
	rate	0.074 (0.066, 0.086)	0.115 (0.093, 0.148)	0.036 (0.028, 0.044)	0.114 (0.096, 0.14)	0.113 (0.095, 0.139)

By subgroup combinations:

subtype	var	Control	Hormone_therapies	Taxel_therapies	Carboplatin	Niraparib
—-	graduation	0	287	139	233	215
	futility	0	0	0	0	0
	max_n	0	16	16	12	13
	n	111 (89, 130)	36 (17, 95)	31 (11, 88)	35 (10, 88)	34 (10, 91)
	n_unique	104 (83, 122)	33 (16, 91)	29 (10, 83)	32 (9, 83)	31 (9, 86)
	post_p	NA (NA, NA)	0.47 (0.11, 0.86)	0.47 (0.1, 0.9)	0.43 (0.11, 0.86)	0.45 (0.1, 0.86)
	rate	0.113 (0.099, 0.127)	0.116 (0.096, 0.156)	0.114 (0.089, 0.171)	0.118 (0.095, 0.182)	0.117 (0.092, 0.184)
—+	graduation	0	377	372	352	329
	futility	0	0	0	0	0
	max_n	0	13	34	15	12
	n	21 (14, 29)	6 (2, 16)	9 (3, 22)	6 (2, 17)	6 (2, 18)
	n_unique	19 (12, 26)	5 (2, 15)	8 (2, 20)	5 (2, 16)	6 (2, 17)
	post_p	NA (NA, NA)	0.27 (0.11, 0.56)	0.9 (0.57, 0.99)	0.27 (0.11, 0.54)	0.28 (0.11, 0.55)
	rate	0.075 (0.052, 0.108)	0.125 (0.075, 0.268)	0.036 (0.02, 0.071)	0.129 (0.077, 0.286)	0.124 (0.075, 0.342)
–+-	graduation	0	92	56	85	78
	futility	0	0	0	0	0
	max_n	0	6	31	2	22
	n	62 (50, 76)	26 (9, 57)	22 (7, 51)	24 (7, 55)	25 (8, 55)
	n_unique	57 (45, 71)	25 (9, 54)	20 (6, 48)	22 (6, 52)	23 (7, 52)
	post_p	NA (NA, NA)	0.44 (0.13, 0.9)	0.46 (0.1, 0.85)	0.46 (0.12, 0.88)	0.44 (0.1, 0.89)
	rate	0.113 (0.094, 0.137)	0.118 (0.091, 0.18)	0.12 (0.089, 0.216)	0.119 (0.09, 0.213)	0.12 (0.088, 0.206)
–++	graduation	0	260	342	277	257
	futility	0	0	0	0	0
	max_n	0	5	43	5	19
	n	46 (34, 56)	10 (5, 30)	25 (10, 49)	10 (4, 32)	10 (4, 31)
	n_unique	42 (31, 52)	9 (4, 28)	23 (9, 45)	9 (3, 30)	9 (4, 29)
	post_p	NA (NA, NA)	0.18 (0.05, 0.45)	0.99 (0.87, 1)	0.18 (0.05, 0.45)	0.19 (0.06, 0.46)
	rate	0.075 (0.057, 0.095)	0.12 (0.083, 0.22)	0.036 (0.024, 0.052)	0.122 (0.086, 0.238)	0.121 (0.085, 0.215)
-+–	graduation	0	293	161	261	243
	futility	0	0	0	0	0
	max_n	0	14	16	12	13
	n	21 (14, 28)	6 (1, 18)	7 (2, 19)	9 (3, 21)	9 (3, 21)
	n_unique	19 (13, 26)	5 (1, 17)	6 (2, 17)	8 (3, 19)	8 (3, 20)
	post_p	NA (NA, NA)	0.46 (0.22, 0.82)	0.49 (0.17, 0.83)	0.45 (0.18, 0.82)	0.46 (0.19, 0.83)
	rate	0.115 (0.084, 0.157)	0.133 (0.074, 0.371)	0.123 (0.072, 0.275)	0.128 (0.082, 0.248)	0.123 (0.081, 0.251)
-+-+	graduation	0	380	380	359	344
	futility	0	0	0	0	0
	max_n	0	12	34	15	12
	n	21 (14, 27)	5 (1, 17)	6 (1, 20)	7 (3, 20)	7 (3, 19)
	n_unique	19 (12, 26)	4 (1, 16)	6 (1, 18)	7 (3, 18)	6 (3, 17)
	post_p	NA (NA, NA)	0.3 (0.12, 0.59)	0.88 (0.55, 0.99)	0.25 (0.1, 0.54)	0.26 (0.09, 0.54)
	rate	0.075 (0.052, 0.108)	0.125 (0.071, 0.299)	0.034 (0.015, 0.072)	0.123 (0.077, 0.274)	0.123 (0.077, 0.238)
-++-	graduation	0	111	85	140	119
	futility	0	0	0	0	0
	max_n	0	6	31	2	22
	n	11 (7, 17)	5 (1, 11)	4 (1, 10)	5 (2, 12)	6 (2, 12)
	n_unique	10 (6, 15)	4 (1, 10)	4 (1, 9)	5 (2, 11)	5 (2, 11)
	post_p	NA (NA, NA)	0.47 (0.23, 0.78)	0.46 (0.22, 0.78)	0.46 (0.22, 0.81)	0.46 (0.24, 0.8)
	rate	0.116 (0.073, 0.174)	0.123 (0.071, 0.374)	0.128 (0.068, 0.401)	0.129 (0.071, 0.318)	0.124 (0.072, 0.324)
-+++	graduation	0	270	355	296	273
	futility	0	0	0	0	0
	max_n	0	5	43	5	19
	n	12 (7, 17)	4 (1, 12)	4 (1, 12)	5 (2, 11)	6 (2, 11)
	n_unique	11 (6, 16)	4 (1, 11)	4 (0, 11)	4 (2, 10)	5 (2, 11)
	post_p	NA (NA, NA)	0.35 (0.17, 0.61)	0.8 (0.46, 0.97)	0.34 (0.16, 0.61)	0.34 (0.15, 0.64)
	rate	0.077 (0.047, 0.133)	0.126 (0.067, 0.398)	0.036 (0.005, 0.101)	0.131 (0.072, 0.288)	0.12 (0.065, 0.27)
+—	graduation	0	19	20	7	4
	futility	0	0	0	0	0
	max_n	0	0	0	0	0
	n	19 (13, 26)	8 (3, 18)	11 (4, 21)	8 (3, 18)	8 (3, 17)
	n_unique	18 (12, 24)	8 (3, 16)	9 (4, 18)	8 (3, 16)	7 (3, 16)
	post_p	NA (NA, NA)	0.44 (0.16, 0.8)	0.47 (0.18, 0.83)	0.48 (0.18, 0.85)	0.46 (0.2, 0.83)
	rate	0.116 (0.082, 0.162)	0.131 (0.082, 0.302)	0.12 (0.082, 0.238)	0.123 (0.075, 0.286)	0.126 (0.076, 0.295)
+–+	graduation	0	233	338	241	227
	futility	0	0	0	0	0
	max_n	0	0	21	3	2
	n	17 (11, 23)	6 (2, 13)	9 (3, 18)	6 (2, 13)	6 (2, 13)
	n_unique	15 (10, 22)	5 (2, 12)	8 (3, 17)	5 (2, 12)	5 (2, 12)
	post_p	NA (NA, NA)	0.3 (0.14, 0.57)	0.88 (0.56, 0.98)	0.32 (0.13, 0.58)	0.3 (0.12, 0.61)
	rate	0.075 (0.047, 0.114)	0.127 (0.073, 0.319)	0.038 (0.018, 0.071)	0.122 (0.07, 0.319)	0.128 (0.071, 0.309)
+-+-	graduation	0	92	56	85	78
	futility	0	0	0	0	0
	max_n	0	6	31	2	22
	n	16 (10, 22)	7 (2, 14)	8 (3, 16)	6 (2, 14)	7 (2, 15)
	n_unique	14 (9, 20)	6 (2, 13)	7 (3, 15)	6 (2, 13)	6 (2, 14)
	post_p	NA (NA, NA)	0.45 (0.2, 0.8)	0.47 (0.18, 0.82)	0.43 (0.19, 0.8)	0.44 (0.22, 0.8)
	rate	0.113 (0.075, 0.163)	0.127 (0.074, 0.306)	0.121 (0.073, 0.243)	0.132 (0.074, 0.312)	0.126 (0.073, 0.302)
+-++	graduation	0	260	342	277	257
	futility	0	0	0	0	0
	max_n	0	5	43	5	19
	n	17 (11, 23)	6 (2, 13)	8 (2, 18)	5 (2, 13)	6 (2, 15)
	n_unique	15 (10, 22)	5 (2, 12)	8 (2, 16)	5 (2, 11)	5 (2, 14)
	post_p	NA (NA, NA)	0.29 (0.13, 0.57)	0.89 (0.55, 0.99)	0.3 (0.13, 0.54)	0.3 (0.13, 0.57)
	rate	0.074 (0.048, 0.115)	0.128 (0.073, 0.293)	0.035 (0.017, 0.072)	0.13 (0.072, 0.287)	0.125 (0.071, 0.357)
++–	graduation	0	55	53	83	68
	futility	0	0	0	0	0
	max_n	0	0	0	0	0
	n	11 (7, 16)	5 (2, 10)	4 (1, 10)	6 (2, 12)	5 (2, 12)
	n_unique	10 (6, 15)	5 (1, 10)	4 (1, 9)	5 (2, 11)	5 (2, 11)
	post_p	NA (NA, NA)	0.47 (0.22, 0.83)	0.45 (0.21, 0.76)	0.48 (0.23, 0.81)	0.45 (0.21, 0.81)
	rate	0.114 (0.073, 0.185)	0.129 (0.059, 0.348)	0.129 (0.073, 0.375)	0.126 (0.069, 0.289)	0.128 (0.07, 0.377)
++-+	graduation	0	245	352	265	252
	futility	0	0	0	0	0
	max_n	0	0	21	3	2
	n	12 (7, 18)	5 (1, 11)	4 (0, 11)	5 (2, 11)	5 (2, 12)
	n_unique	11 (7, 17)	4 (1, 10)	4 (0, 10)	5 (2, 10)	5 (2, 11)
	post_p	NA (NA, NA)	0.35 (0.16, 0.61)	0.78 (0.47, 0.96)	0.32 (0.14, 0.57)	0.32 (0.14, 0.62)
	rate	0.076 (0.046, 0.122)	0.121 (0.066, 0.321)	0.036 (0, 0.113)	0.131 (0.072, 0.331)	0.126 (0.073, 0.297)
+++-	graduation	0	111	85	140	119
	futility	0	0	0	0	0
	max_n	0	6	31	2	22
	n	11 (7, 17)	5 (2, 11)	5 (1, 10)	5 (2, 12)	6 (2, 13)
	n_unique	10 (6, 15)	4 (1, 11)	4 (1, 9)	5 (2, 11)	6 (2, 12)
	post_p	NA (NA, NA)	0.49 (0.24, 0.81)	0.46 (0.22, 0.77)	0.46 (0.23, 0.79)	0.48 (0.22, 0.82)
	rate	0.118 (0.073, 0.191)	0.124 (0.068, 0.357)	0.131 (0.069, 0.331)	0.131 (0.072, 0.36)	0.122 (0.07, 0.289)
++++	graduation	0	270	355	296	273
	futility	0	0	0	0	0
	max_n	0	5	43	5	19
	n	12 (8, 17)	4 (1, 11)	4 (0, 12)	5 (2, 12)	5 (2, 11)
	n_unique	11 (7, 16)	4 (1, 10)	4 (0, 11)	4 (2, 11)	4 (2, 10)
	post_p	NA (NA, NA)	0.35 (0.15, 0.62)	0.81 (0.48, 0.95)	0.34 (0.17, 0.59)	0.32 (0.14, 0.59)
	rate	0.076 (0.044, 0.131)	0.129 (0.065, 0.373)	0.035 (0.008, 0.091)	0.119 (0.071, 0.296)	0.125 (0.073, 0.308)

Median results over time

Signatures:

Posterior probabilities

Randomization probabilities

PFS rates

Subgroup combinations:

Posterior probabilities

Randomization probabilities

PFS rates

Median results at stop

By signature

Graduation:

signature	var	Hormone_therapies	Taxel_therapies	Carboplatin	Niraparib
all	count	4	20	1
	time_stop	4 (4, 6)	6 (5, 23)	5 (5, 5)
	n_trt	36 (28, 41)	40 (27, 153)	29 (29, 29)
	n_control	44 (38, 62)	66 (48, 250)	48 (48, 48)
	post_p	0.87 (0.86, 0.89)	0.96 (0.89, 1)	0.92 (0.92, 0.92)
	order	1 (1, 1)	1 (1, 1.2)	1 (1, 1)
TP53- & AR-	count	30	115	9	6
	time_stop	10 (7, 16)	14 (10, 28)	14 (12, 20)	16 (10, 18)
	n_trt	32 (26, 45)	32 (25, 71)	36 (31, 44)	32 (27, 42)
	n_control	41 (27, 66)	60 (37, 120)	63 (49, 77)	68 (43, 90)
	post_p	0.91 (0.85, 0.96)	0.95 (0.88, 1)	0.91 (0.86, 0.96)	0.96 (0.86, 0.99)
	order	1 (1, 2)	1 (1, 2)	1 (1, 2)	1 (1, 2)
TP53+	count	4	36	3	1
	time_stop	10 (9, 12)	14 (9, 28)	9 (8, 10)	8 (8, 8)
	n_trt	28 (25, 35)	45 (27, 101)	29 (27, 32)	31 (31, 31)
	n_control	40 (32, 49)	66 (34, 130)	32 (31, 34)	27 (27, 27)
	post_p	0.98 (0.92, 0.99)	0.99 (0.95, 1)	0.98 (0.96, 0.98)	0.96 (0.96, 0.96)
	order	1 (1, 1.7)	1 (1, 2.5)	2 (1.2, 2)	1 (1, 1)
DRD+	count		32
	time_stop		20 (16, 31)
	n_trt		29 (25, 47)
	n_control		55 (38, 90)
	post_p		0.99 (0.92, 1)
	order		1.5 (1, 3)
TEfus+	count	1	325
	time_stop	11 (11, 11)	18 (10, 31)
	n_trt	27 (27, 27)	55 (28, 113)
	n_control	47 (47, 47)	67 (37, 137)
	post_p	0.87 (0.87, 0.87)	1 (0.97, 1)
	order	1 (1, 1)	1 (1, 2)

Futility:

signature	var	Hormone_therapies	Taxel_therapies	Carboplatin	Niraparib
all	count	15		6	4
	time_stop	5 (3, 32)		27 (10, 34)	28 (22, 30)
	n_trt	31 (26, 121)		94 (40, 180)	101 (79, 127)
	n_control	45 (29, 384)		268 (110, 431)	314 (240, 329)
	post_p	0.05 (0, 0.26)		0 (0, 0.02)	0.01 (0, 0.02)
	order	1 (1, 5.2)		3.5 (1, 6.5)	4.5 (3.3, 7.1)
TP53- & AR-	count	244	6	221	208
	time_stop	19 (9, 32)	22 (14, 31)	21 (14, 32)	22 (13, 33)
	n_trt	40 (26, 91)	36 (28, 78)	38 (26, 86)	39 (25, 87)
	n_control	78 (33, 152)	96 (58, 142)	95 (55, 151)	97 (59, 156)
	post_p	0.14 (0.03, 0.25)	0.19 (0.04, 0.23)	0.14 (0.05, 0.24)	0.14 (0.04, 0.25)
	order	1 (1, 4)	2 (1, 3)	2 (1, 4)	2 (1, 4)
TP53+	count	74	1	79	77
	time_stop	25 (13, 33)	11 (11, 11)	23 (13, 32)	23 (13, 34)
	n_trt	50 (30, 86)	28 (28, 28)	47 (29, 77)	47 (27, 74)
	n_control	114 (57, 172)	40 (40, 40)	106 (58, 175)	109 (54, 172)
	post_p	0.03 (0, 0.17)	0.14 (0.14, 0.14)	0.04 (0.01, 0.17)	0.04 (0.01, 0.13)
	order	3 (1, 5)	1 (1, 1)	2 (1, 6)	2 (1, 5)
DRD+	count	41	2	81	67
	time_stop	28 (19, 35)	24 (19, 28)	22 (14, 31)	20 (14, 32)
	n_trt	33 (25, 50)	26 (26, 26)	35 (26, 50)	35 (26, 55)
	n_control	87 (57, 111)	58 (40, 76)	57 (32, 99)	56 (33, 102)
	post_p	0.03 (0, 0.2)	0.06 (0.02, 0.1)	0.03 (0.01, 0.16)	0.03 (0, 0.16)
	order	4 (2, 7)	2 (1.2, 2.8)	3 (1, 5)	3 (1, 6.4)
TEfus+	count	218		239	227
	time_stop	26 (16, 35)		26 (16, 34)	26 (17, 35)
	n_trt	42 (26, 77)		44 (27, 76)	45 (30, 83)
	n_control	102 (58, 155)		105 (52, 152)	106 (64, 155)
	post_p	0.01 (0, 0.08)		0.01 (0, 0.09)	0.01 (0, 0.08)
	order	3 (1, 5)		3 (1, 5)	3 (1, 5)

By subgroup combinations

Graduation:

signature	treatment	var	—-	—+	–+-	–++	-+–	-+-+	-++-	-+++	+—	+–+	+-+-	+-++	++–	++-+	+++-	++++
all	Hormone_therapies	count	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4
		time	4 (4, 6)	4 (4, 6)	4 (4, 6)	4 (4, 6)	4 (4, 6)	4 (4, 6)	4 (4, 6)	4 (4, 6)	4 (4, 6)	4 (4, 6)	4 (4, 6)	4 (4, 6)	4 (4, 6)	4 (4, 6)	4 (4, 6)	4 (4, 6)
		n	20 (15, 23)	2 (1, 2)	6 (2, 12)	2 (1, 7)	0 (0, 0)	0 (0, 2)	0 (0, 0)	0 (0, 0)	0 (0, 2)	0 (0, 1)	1 (0, 1)	1 (0, 2)	0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		post_p	0.63 (0.57, 0.75)	0.54 (0.53, 0.56)	0.53 (0.51, 0.62)	0.6 (0.55, 0.63)	NA (NA, NA)	0.56 (0.56, 0.56)	NA (NA, NA)	NA (NA, NA)	0.59 (0.55, 0.62)	NA (NA, NA)	0.53 (0.52, 0.54)	0.52 (0.52, 0.53)	0.53 (0.53, 0.53)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
		r_prob	0.44 (0.44, 0.44)	0.35 (0.35, 0.35)	0.33 (0.33, 0.33)	0.18 (0.18, 0.18)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.18 (0.18, 0.18)	0.18 (0.18, 0.18)	0.12 (0.12, 0.12)	0.12 (0.12, 0.12)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate	0.073 (0.04, 0.083)	0 (0, 0)	0.086 (0.023, 0.097)	0 (0, 0)	NA (NA, NA)	0.55 (0.11, 0.99)	NA (NA, NA)	NA (NA, NA)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
	Taxel_therapies	count	20	20	20	20	20	20	20	20	20	20	20	20	20	20	20	20
		time	6 (5, 23)	6 (5, 23)	6 (5, 23)	6 (5, 23)	6 (5, 23)	6 (5, 23)	6 (5, 23)	6 (5, 23)	6 (5, 23)	6 (5, 23)	6 (5, 23)	6 (5, 23)	6 (5, 23)	6 (5, 23)	6 (5, 23)	6 (5, 23)
		n	7 (4, 56)	3 (1, 10)	6 (2, 13)	8 (3, 18)	1 (0, 5)	2 (0, 6)	0 (0, 2)	0 (0, 1)	4 (2, 10)	3 (1, 8)	3 (1, 8)	2 (1, 5)	0 (0, 5)	1 (0, 3)	1 (0, 5)	0 (0, 2)
		post_p	0.62 (0.55, 0.76)	0.61 (0.54, 0.74)	0.6 (0.53, 0.73)	0.61 (0.56, 0.77)	0.58 (0.5, 0.66)	0.56 (0.52, 0.93)	0.54 (0.51, 0.61)	0.58 (0.53, 0.82)	0.56 (0.51, 0.64)	0.55 (0.5, 0.76)	0.55 (0.51, 0.68)	0.56 (0.51, 0.77)	0.55 (0.53, 0.8)	0.55 (0.52, 0.88)	0.53 (0.51, 0.6)	0.56 (0.51, 0.71)
		r_prob	0.11 (0.11, 0.11)	0.29 (0.29, 0.29)	0.17 (0.17, 0.17)	0.41 (0.41, 0.41)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.41 (0.41, 0.41)	0.41 (0.41, 0.41)	0.37 (0.37, 0.37)	0.37 (0.37, 0.37)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate	0.065 (0, 0.098)	0 (0, 0.051)	0.015 (0, 0.116)	0.023 (0, 0.067)	0 (0, 0.089)	0 (0, 0.056)	0 (0, 0.149)	0 (0, 0.015)	0.051 (0, 0.148)	0 (0, 0.075)	0.06 (0, 0.142)	0 (0, 0.028)	0 (0, 0.119)	0 (0, 0.025)	0 (0, 0.157)	0 (0, 0.013)
	Carboplatin	count	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1
		time	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)
		n	1 (1, 1)	0 (0, 0)	8 (8, 8)	1 (1, 1)	2 (2, 2)	3 (3, 3)	3 (3, 3)	2 (2, 2)	0 (0, 0)	0 (0, 0)	0 (0, 0)	2 (2, 2)	2 (2, 2)	1 (1, 1)	2 (2, 2)	2 (2, 2)
		post_p	0.55 (0.55, 0.55)	NA (NA, NA)	0.89 (0.89, 0.89)	0.51 (0.51, 0.51)	0.52 (0.52, 0.52)	0.55 (0.55, 0.55)	0.56 (0.56, 0.56)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.56 (0.56, 0.56)	NA (NA, NA)	0.54 (0.54, 0.54)	0.5 (0.5, 0.5)	0.51 (0.51, 0.51)
		r_prob	0 (0, 0)	0 (0, 0)	0.08 (0.08, 0.08)	0 (0, 0)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0 (0, 0)	0 (0, 0)	0.06 (0.06, 0.06)	0.06 (0.06, 0.06)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0 (0, 0)	NA (NA, NA)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0 (0, 0)	0.173 (0.173, 0.173)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53- & AR-	Hormone_therapies	count	30	30			30	30
		time	10 (7, 16)	10 (7, 16)			10 (7, 16)	10 (7, 16)
		n	26 (19, 39)	4 (1, 5)			2 (0, 4)	2 (0, 4)
		post_p	0.83 (0.73, 0.9)	0.55 (0.51, 0.69)			0.59 (0.54, 0.73)	0.57 (0.52, 0.65)
		r_prob	0.44 (0.44, 0.44)	0.35 (0.35, 0.35)			0 (0, 0)	0 (0, 0)
		rate	0.078 (0.054, 0.106)	0.066 (0, 0.144)			0 (0, 0.093)	0 (0, 0.068)
	Taxel_therapies	count	115	115			115	115
		time	14 (10, 28)	14 (10, 28)			14 (10, 28)	14 (10, 28)
		n	21 (15, 48)	5 (2, 13)			4 (0, 9)	3 (1, 10)
		post_p	0.8 (0.72, 0.93)	0.73 (0.54, 0.92)			0.62 (0.51, 0.81)	0.68 (0.54, 0.85)
		r_prob	0.11 (0.11, 0.11)	0.29 (0.29, 0.29)			0 (0, 0)	0 (0, 0)
		rate	0.083 (0.048, 0.105)	0.026 (0, 0.07)			0.06 (0, 0.134)	0 (0, 0.057)
	Carboplatin	count	9	9			9	9
		time	14 (12, 20)	14 (12, 20)			14 (12, 20)	14 (12, 20)
		n	19 (17, 28)	4 (2, 4)			5 (2, 10)	5 (3, 7)
		post_p	0.86 (0.75, 0.93)	0.54 (0.52, 0.65)			0.7 (0.53, 0.81)	0.54 (0.51, 0.77)
		r_prob	0 (0, 0)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.071 (0.055, 0.11)	0.038 (0, 0.084)			0.093 (0.062, 0.155)	0.06 (0.025, 0.071)
	Niraparib	count	6	6			6	6
		time	16 (10, 18)	16 (10, 18)			16 (10, 18)	16 (10, 18)
		n	18 (16, 25)	3 (2, 3)			4 (4, 7)	5 (4, 10)
		post_p	0.84 (0.74, 0.93)	0.56 (0.51, 0.67)			0.83 (0.57, 0.88)	0.68 (0.53, 0.77)
		r_prob	0 (0, 0)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.059 (0.041, 0.091)	0.066 (0, 0.116)			0.04 (0.016, 0.087)	0.064 (0.028, 0.103)
TP53+	Hormone_therapies	count			4	4			4	4			4	4			4	4
		time			10 (9, 12)	10 (9, 12)			10 (9, 12)	10 (9, 12)			10 (9, 12)	10 (9, 12)			10 (9, 12)	10 (9, 12)
		n			18 (13, 20)	6 (3, 7)			0 (0, 2)	1 (0, 2)			2 (1, 3)	1 (0, 1)			2 (0, 3)	0 (0, 2)
		post_p			0.88 (0.78, 0.92)	0.72 (0.67, 0.75)			0.53 (0.53, 0.54)	0.53 (0.52, 0.54)			0.58 (0.53, 0.68)	0.53 (0.52, 0.53)			0.6 (0.54, 0.67)	NA (NA, NA)
		r_prob			0.33 (0.33, 0.33)	0.18 (0.18, 0.18)			0 (0, 0)	0 (0, 0)			0.12 (0.12, 0.12)	0.12 (0.12, 0.12)			0 (0, 0)	0 (0, 0)
		rate			0.056 (0.035, 0.074)	0 (0, 0)			0.081 (0.016, 0.146)	0 (0, 0)			0.038 (0, 0.103)	0 (0, 0)			0 (0, 0)	0.044 (0.009, 0.079)
	Taxel_therapies	count			36	36			36	36			36	36			36	36
		time			14 (9, 28)	14 (9, 28)			14 (9, 28)	14 (9, 28)			14 (9, 28)	14 (9, 28)			14 (9, 28)	14 (9, 28)
		n			16 (8, 35)	14 (6, 36)			2 (0, 5)	2 (0, 6)			4 (2, 10)	4 (1, 12)			2 (0, 5)	2 (0, 6)
		post_p			0.77 (0.7, 0.85)	0.82 (0.69, 0.99)			0.55 (0.52, 0.7)	0.6 (0.53, 0.9)			0.62 (0.51, 0.86)	0.64 (0.51, 0.84)			0.56 (0.52, 0.75)	0.68 (0.52, 0.84)
		r_prob			0.17 (0.17, 0.17)	0.41 (0.41, 0.41)			0 (0, 0)	0 (0, 0)			0.37 (0.37, 0.37)	0.37 (0.37, 0.37)			0 (0, 0)	0 (0, 0)
		rate			0.071 (0.041, 0.102)	0.03 (0.012, 0.054)			0.069 (0, 0.119)	0 (0, 0.042)			0.071 (0.013, 0.12)	0.031 (0, 0.078)			0.083 (0, 0.126)	0 (0, 0.067)
	Carboplatin	count			3	3			3	3			3	3			3	3
		time			9 (8, 10)	9 (8, 10)			9 (8, 10)	9 (8, 10)			9 (8, 10)	9 (8, 10)			9 (8, 10)	9 (8, 10)
		n			12 (12, 13)	2 (1, 4)			2 (1, 4)	2 (1, 4)			1 (0, 2)	3 (2, 3)			2 (1, 3)	4 (2, 5)
		post_p			0.79 (0.74, 0.85)	0.59 (0.55, 0.6)			0.58 (0.57, 0.66)	0.55 (0.53, 0.58)			0.55 (0.54, 0.57)	0.58 (0.56, 0.6)			0.54 (0.51, 0.56)	0.54 (0.52, 0.56)
		r_prob			0.08 (0.08, 0.08)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.06 (0.06, 0.06)	0.06 (0.06, 0.06)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate			0.054 (0.027, 0.058)	0 (0, 0.039)			0 (0, 0)	0 (0, 0.078)			0.066 (0.013, 0.119)	0 (0, 0)			0.088 (0.018, 0.155)	0 (0, 0.039)
	Niraparib	count			1	1			1	1			1	1			1	1
		time			8 (8, 8)	8 (8, 8)			8 (8, 8)	8 (8, 8)			8 (8, 8)	8 (8, 8)			8 (8, 8)	8 (8, 8)
		n			11 (11, 11)	2 (2, 2)			4 (4, 4)	3 (3, 3)			2 (2, 2)	2 (2, 2)			4 (4, 4)	3 (3, 3)
		post_p			0.79 (0.79, 0.79)	0.53 (0.53, 0.53)			0.52 (0.52, 0.52)	0.51 (0.51, 0.51)			0.61 (0.61, 0.61)	0.54 (0.54, 0.54)			0.57 (0.57, 0.57)	0.59 (0.59, 0.59)
		r_prob			0.08 (0.08, 0.08)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.06 (0.06, 0.06)	0.06 (0.06, 0.06)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate			0.031 (0.031, 0.031)	0 (0, 0)			0.053 (0.053, 0.053)	0.067 (0.067, 0.067)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)
DRD+	Taxel_therapies	count					32	32	32	32					32	32	32	32
		time					20 (16, 31)	20 (16, 31)	20 (16, 31)	20 (16, 31)					20 (16, 31)	20 (16, 31)	20 (16, 31)	20 (16, 31)
		n					4 (1, 15)	6 (3, 11)	4 (0, 7)	3 (0, 7)					2 (1, 5)	2 (1, 8)	4 (0, 7)	4 (0, 6)
		post_p					0.62 (0.54, 0.79)	0.83 (0.59, 0.95)	0.64 (0.53, 0.77)	0.68 (0.53, 0.88)					0.57 (0.52, 0.82)	0.69 (0.54, 0.89)	0.64 (0.52, 0.86)	0.64 (0.53, 0.82)
		r_prob					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate					0.076 (0, 0.107)	0.027 (0, 0.057)	0.074 (0.017, 0.129)	0.025 (0, 0.077)					0.083 (0, 0.153)	0.004 (0, 0.065)	0.059 (0, 0.154)	0.035 (0, 0.076)
TEfus+	Hormone_therapies	count		1		1		1		1		1		1		1		1
		time		11 (11, 11)		11 (11, 11)		11 (11, 11)		11 (11, 11)		11 (11, 11)		11 (11, 11)		11 (11, 11)		11 (11, 11)
		n		5 (5, 5)		7 (7, 7)		4 (4, 4)		3 (3, 3)		0 (0, 0)		3 (3, 3)		3 (3, 3)		2 (2, 2)
		post_p		0.67 (0.67, 0.67)		0.79 (0.79, 0.79)		0.51 (0.51, 0.51)		0.54 (0.54, 0.54)		NA (NA, NA)		0.52 (0.52, 0.52)		0.51 (0.51, 0.51)		0.63 (0.63, 0.63)
		r_prob		0.35 (0.35, 0.35)		0.18 (0.18, 0.18)		0 (0, 0)		0 (0, 0)		0.18 (0.18, 0.18)		0.12 (0.12, 0.12)		0 (0, 0)		0 (0, 0)
		rate		0 (0, 0)		0.032 (0.032, 0.032)		0.08 (0.08, 0.08)		0.087 (0.087, 0.087)		NA (NA, NA)		0.092 (0.092, 0.092)		0.133 (0.133, 0.133)		0 (0, 0)
	Taxel_therapies	count		325		325		325		325		325		325		325		325
		time		18 (10, 31)		18 (10, 31)		18 (10, 31)		18 (10, 31)		18 (10, 31)		18 (10, 31)		18 (10, 31)		18 (10, 31)
		n		7 (2, 17)		19 (10, 37)		5 (1, 14)		3 (0, 10)		7 (3, 15)		6 (2, 15)		3 (0, 9)		3 (0, 9)
		post_p		0.75 (0.55, 0.95)		0.9 (0.73, 0.99)		0.72 (0.54, 0.94)		0.66 (0.53, 0.93)		0.74 (0.55, 0.94)		0.74 (0.54, 0.95)		0.66 (0.53, 0.89)		0.65 (0.53, 0.89)
		r_prob		0.29 (0.29, 0.29)		0.41 (0.41, 0.41)		0 (0, 0)		0 (0, 0)		0.41 (0.41, 0.41)		0.37 (0.37, 0.37)		0 (0, 0)		0 (0, 0)
		rate		0.033 (0, 0.067)		0.035 (0.014, 0.054)		0.025 (0, 0.067)		0.012 (0, 0.068)		0.033 (0, 0.062)		0.028 (0, 0.063)		0.003 (0, 0.074)		0.007 (0, 0.068)

Futility:

signature	treatment	var	—-	—+	–+-	–++	-+–	-+-+	-++-	-+++	+—	+–+	+-+-	+-++	++–	++-+	+++-	++++
all	Hormone_therapies	count	15	15	15	15	15	15	15	15	15	15	15	15	15	15	15	15
		time	5 (3, 32)	5 (3, 32)	5 (3, 32)	5 (3, 32)	5 (3, 32)	5 (3, 32)	5 (3, 32)	5 (3, 32)	5 (3, 32)	5 (3, 32)	5 (3, 32)	5 (3, 32)	5 (3, 32)	5 (3, 32)	5 (3, 32)	5 (3, 32)
		n	15 (11, 49)	2 (1, 6)	7 (4, 18)	4 (1, 10)	0 (0, 5)	0 (0, 4)	0 (0, 3)	0 (0, 5)	2 (0, 8)	1 (0, 7)	1 (0, 4)	1 (0, 4)	0 (0, 5)	0 (0, 5)	0 (0, 4)	0 (0, 6)
		post_p	0.28 (0.11, 0.47)	0.43 (0.29, 0.49)	0.36 (0.27, 0.46)	0.42 (0.14, 0.49)	0.41 (0.24, 0.48)	0.34 (0.19, 0.43)	0.38 (0.25, 0.46)	0.21 (0.14, 0.36)	0.29 (0.19, 0.46)	0.34 (0.19, 0.5)	0.42 (0.18, 0.46)	0.4 (0.18, 0.48)	0.28 (0.18, 0.43)	0.38 (0.24, 0.48)	0.42 (0.24, 0.46)	0.33 (0.2, 0.39)
		r_prob	0.44 (0.44, 0.44)	0.35 (0.35, 0.35)	0.33 (0.33, 0.33)	0.18 (0.18, 0.18)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.18 (0.18, 0.18)	0.18 (0.18, 0.18)	0.12 (0.12, 0.12)	0.12 (0.12, 0.12)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate	0.15 (0.098, 0.204)	0.17 (0, 0.364)	0.161 (0.119, 0.32)	0.151 (0.022, 0.429)	0.216 (0.144, 0.685)	0.293 (0.112, 0.378)	0.177 (0, 1.416)	0.212 (0.081, 0.492)	0.182 (0, 0.717)	0.048 (0, 0.172)	0.218 (0, 0.573)	0.236 (0.057, 0.754)	0.179 (0.059, 0.466)	0.147 (0.043, 0.195)	0.231 (0.058, 0.462)	0.219 (0.063, 0.49)
	Carboplatin	count	6	6	6	6	6	6	6	6	6	6	6	6	6	6	6	6
		time	27 (10, 34)	27 (10, 34)	27 (10, 34)	27 (10, 34)	27 (10, 34)	27 (10, 34)	27 (10, 34)	27 (10, 34)	27 (10, 34)	27 (10, 34)	27 (10, 34)	27 (10, 34)	27 (10, 34)	27 (10, 34)	27 (10, 34)	27 (10, 34)
		n	14 (6, 34)	6 (1, 14)	12 (2, 26)	4 (2, 11)	4 (2, 11)	6 (2, 13)	4 (2, 7)	4 (1, 7)	4 (2, 14)	4 (2, 12)	3 (0, 8)	4 (2, 8)	3 (0, 10)	4 (2, 10)	2 (2, 4)	2 (2, 12)
		post_p	0.38 (0.31, 0.44)	0.29 (0.22, 0.4)	0.19 (0.11, 0.39)	0.29 (0.13, 0.42)	0.33 (0.24, 0.42)	0.33 (0.16, 0.4)	0.35 (0.25, 0.48)	0.38 (0.15, 0.47)	0.39 (0.26, 0.47)	0.26 (0.13, 0.46)	0.27 (0.21, 0.45)	0.34 (0.2, 0.37)	0.16 (0.13, 0.46)	0.4 (0.24, 0.44)	0.41 (0.38, 0.48)	0.36 (0.21, 0.46)
		r_prob	0 (0, 0)	0 (0, 0)	0.08 (0.08, 0.08)	0 (0, 0)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0 (0, 0)	0 (0, 0)	0.06 (0.06, 0.06)	0.06 (0.06, 0.06)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.136 (0.126, 0.184)	0.141 (0.103, 0.318)	0.148 (0.128, 0.917)	0.114 (0.101, 1.36)	0.149 (0.112, 0.504)	0.184 (0.113, 0.384)	0.145 (0.117, 0.206)	0.183 (0.117, 2.268)	0.143 (0.121, 0.197)	0.124 (0.055, 0.168)	0.182 (0.071, 0.213)	0.203 (0.096, 0.261)	0.492 (0.111, 1.028)	0.152 (0.081, 0.303)	0.186 (0.089, 0.687)	0.121 (0.092, 0.245)
	Niraparib	count	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4
		time	28 (22, 30)	28 (22, 30)	28 (22, 30)	28 (22, 30)	28 (22, 30)	28 (22, 30)	28 (22, 30)	28 (22, 30)	28 (22, 30)	28 (22, 30)	28 (22, 30)	28 (22, 30)	28 (22, 30)	28 (22, 30)	28 (22, 30)	28 (22, 30)
		n	15 (8, 33)	4 (3, 6)	18 (11, 24)	6 (4, 11)	10 (4, 15)	4 (3, 9)	3 (2, 5)	3 (0, 6)	4 (1, 8)	4 (3, 7)	6 (4, 7)	5 (3, 8)	1 (0, 5)	2 (1, 4)	4 (3, 5)	4 (4, 5)
		post_p	0.27 (0.09, 0.38)	0.37 (0.21, 0.45)	0.29 (0.16, 0.44)	0.33 (0.19, 0.48)	0.29 (0.22, 0.42)	0.33 (0.2, 0.43)	0.44 (0.4, 0.46)	0.31 (0.23, 0.35)	0.31 (0.24, 0.38)	0.22 (0.14, 0.29)	0.43 (0.37, 0.47)	0.29 (0.17, 0.39)	0.23 (0.17, 0.29)	0.38 (0.35, 0.46)	0.37 (0.35, 0.45)	0.24 (0.12, 0.36)
		r_prob	0 (0, 0)	0 (0, 0)	0.08 (0.08, 0.08)	0 (0, 0)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0 (0, 0)	0 (0, 0)	0.06 (0.06, 0.06)	0.06 (0.06, 0.06)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.138 (0.12, 0.32)	0.111 (0.081, 0.143)	0.137 (0.108, 0.17)	0.128 (0.08, 0.162)	0.163 (0.142, 0.459)	0.138 (0.087, 0.195)	0.144 (0.107, 0.163)	0.108 (0.101, 0.365)	0.159 (0.152, 0.179)	0.224 (0.15, 0.564)	0.144 (0.111, 0.176)	0.118 (0.081, 0.214)	0.263 (0.167, 0.359)	0.151 (0.067, 0.306)	0.201 (0.141, 0.212)	0.207 (0.126, 0.292)
TP53- & AR-	Hormone_therapies	count	244	244			244	244
		time	19 (9, 32)	19 (9, 32)			19 (9, 32)	19 (9, 32)
		n	26 (16, 72)	5 (2, 11)			4 (0, 10)	4 (1, 12)
		post_p	0.32 (0.12, 0.47)	0.36 (0.18, 0.48)			0.4 (0.23, 0.48)	0.39 (0.18, 0.47)
		r_prob	0.44 (0.44, 0.44)	0.35 (0.35, 0.35)			0 (0, 0)	0 (0, 0)
		rate	0.127 (0.105, 0.166)	0.127 (0.075, 0.281)			0.175 (0.107, 0.569)	0.15 (0.082, 0.477)
	Taxel_therapies	count	6	6			6	6
		time	22 (14, 31)	22 (14, 31)			22 (14, 31)	22 (14, 31)
		n	18 (12, 64)	6 (2, 9)			4 (2, 12)	4 (0, 9)
		post_p	0.22 (0.08, 0.39)	0.36 (0.26, 0.42)			0.42 (0.32, 0.48)	0.46 (0.37, 0.48)
		r_prob	0.11 (0.11, 0.11)	0.29 (0.29, 0.29)			0 (0, 0)	0 (0, 0)
		rate	0.129 (0.114, 0.178)	0.099 (0.071, 0.124)			0.15 (0.084, 0.382)	0.091 (0.073, 0.272)
	Carboplatin	count	221	221			221	221
		time	21 (14, 32)	21 (14, 32)			21 (14, 32)	21 (14, 32)
		n	20 (9, 61)	5 (2, 11)			6 (3, 13)	6 (3, 14)
		post_p	0.37 (0.1, 0.48)	0.36 (0.17, 0.47)			0.38 (0.19, 0.49)	0.31 (0.12, 0.47)
		r_prob	0 (0, 0)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.126 (0.104, 0.195)	0.139 (0.08, 0.401)			0.155 (0.107, 0.305)	0.126 (0.082, 0.282)
	Niraparib	count	208	208			208	208
		time	22 (13, 33)	22 (13, 33)			22 (13, 33)	22 (13, 33)
		n	20 (9, 63)	4 (2, 11)			6 (3, 13)	6 (3, 11)
		post_p	0.37 (0.11, 0.48)	0.35 (0.17, 0.47)			0.38 (0.18, 0.48)	0.32 (0.13, 0.46)
		r_prob	0 (0, 0)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.128 (0.105, 0.201)	0.138 (0.084, 0.467)			0.153 (0.101, 0.301)	0.13 (0.086, 0.259)
TP53+	Hormone_therapies	count			74	74			74	74			74	74			74	74
		time			25 (13, 33)	25 (13, 33)			25 (13, 33)	25 (13, 33)			25 (13, 33)	25 (13, 33)			25 (13, 33)	25 (13, 33)
		n			16 (8, 35)	9 (4, 19)			3 (1, 8)	3 (1, 7)			4 (2, 9)	4 (2, 10)			3 (1, 6)	3 (1, 8)
		post_p			0.35 (0.15, 0.47)	0.27 (0.1, 0.43)			0.39 (0.27, 0.48)	0.34 (0.2, 0.49)			0.38 (0.19, 0.48)	0.3 (0.15, 0.45)			0.41 (0.2, 0.48)	0.38 (0.21, 0.47)
		r_prob			0.33 (0.33, 0.33)	0.18 (0.18, 0.18)			0 (0, 0)	0 (0, 0)			0.12 (0.12, 0.12)	0.12 (0.12, 0.12)			0 (0, 0)	0 (0, 0)
		rate			0.129 (0.104, 0.18)	0.119 (0.088, 0.185)			0.171 (0.109, 0.727)	0.175 (0.088, 0.802)			0.163 (0.099, 0.476)	0.171 (0.093, 0.382)			0.179 (0.117, 0.834)	0.143 (0.078, 0.494)
	Taxel_therapies	count			1	1			1	1			1	1			1	1
		time			11 (11, 11)	11 (11, 11)			11 (11, 11)	11 (11, 11)			11 (11, 11)	11 (11, 11)			11 (11, 11)	11 (11, 11)
		n			8 (8, 8)	8 (8, 8)			2 (2, 2)	1 (1, 1)			2 (2, 2)	2 (2, 2)			3 (3, 3)	2 (2, 2)
		post_p			0.48 (0.48, 0.48)	0.29 (0.29, 0.29)			0.48 (0.48, 0.48)	0.41 (0.41, 0.41)			0.48 (0.48, 0.48)	0.46 (0.46, 0.46)			0.48 (0.48, 0.48)	0.43 (0.43, 0.43)
		r_prob			0.17 (0.17, 0.17)	0.41 (0.41, 0.41)			0 (0, 0)	0 (0, 0)			0.37 (0.37, 0.37)	0.37 (0.37, 0.37)			0 (0, 0)	0 (0, 0)
		rate			0.155 (0.155, 0.155)	0.117 (0.117, 0.117)			0.174 (0.174, 0.174)	1.509 (1.509, 1.509)			0.106 (0.106, 0.106)	0.375 (0.375, 0.375)			0.081 (0.081, 0.081)	0.106 (0.106, 0.106)
	Carboplatin	count			79	79			79	79			79	79			79	79
		time			23 (13, 32)	23 (13, 32)			23 (13, 32)	23 (13, 32)			23 (13, 32)	23 (13, 32)			23 (13, 32)	23 (13, 32)
		n			13 (7, 33)	7 (3, 18)			4 (2, 6)	3 (1, 8)			4 (1, 9)	4 (1, 9)			4 (2, 6)	4 (2, 7)
		post_p			0.35 (0.15, 0.46)	0.3 (0.11, 0.47)			0.36 (0.19, 0.47)	0.4 (0.22, 0.48)			0.38 (0.21, 0.48)	0.35 (0.19, 0.47)			0.43 (0.24, 0.48)	0.38 (0.19, 0.48)
		r_prob			0.08 (0.08, 0.08)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.06 (0.06, 0.06)	0.06 (0.06, 0.06)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate			0.138 (0.109, 0.225)	0.12 (0.083, 0.272)			0.184 (0.104, 0.52)	0.158 (0.085, 0.341)			0.182 (0.104, 0.513)	0.156 (0.085, 0.429)			0.156 (0.098, 0.547)	0.122 (0.075, 0.337)
	Niraparib	count			77	77			77	77			77	77			77	77
		time			23 (13, 34)	23 (13, 34)			23 (13, 34)	23 (13, 34)			23 (13, 34)	23 (13, 34)			23 (13, 34)	23 (13, 34)
		n			12 (6, 29)	7 (3, 18)			3 (2, 6)	4 (1, 8)			4 (2, 9)	4 (1, 10)			5 (2, 8)	3 (1, 6)
		post_p			0.3 (0.12, 0.48)	0.29 (0.11, 0.46)			0.4 (0.25, 0.49)	0.36 (0.15, 0.47)			0.41 (0.21, 0.48)	0.35 (0.17, 0.48)			0.4 (0.27, 0.48)	0.36 (0.17, 0.48)
		r_prob			0.08 (0.08, 0.08)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.06 (0.06, 0.06)	0.06 (0.06, 0.06)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate			0.137 (0.102, 0.282)	0.127 (0.079, 0.331)			0.177 (0.087, 0.379)	0.129 (0.074, 0.304)			0.171 (0.096, 0.327)	0.147 (0.082, 0.497)			0.153 (0.097, 0.285)	0.166 (0.09, 0.54)
DRD+	Hormone_therapies	count					41	41	41	41					41	41	41	41
		time					28 (19, 35)	28 (19, 35)	28 (19, 35)	28 (19, 35)					28 (19, 35)	28 (19, 35)	28 (19, 35)	28 (19, 35)
		n					5 (1, 13)	4 (1, 14)	3 (1, 6)	4 (1, 7)					3 (1, 7)	4 (1, 11)	3 (1, 6)	4 (2, 7)
		post_p					0.37 (0.22, 0.46)	0.34 (0.13, 0.48)	0.4 (0.23, 0.48)	0.34 (0.18, 0.47)					0.36 (0.19, 0.48)	0.37 (0.17, 0.48)	0.36 (0.19, 0.48)	0.34 (0.18, 0.44)
		r_prob					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate					0.173 (0.105, 0.493)	0.153 (0.071, 0.705)	0.179 (0.123, 0.514)	0.15 (0.089, 0.719)					0.18 (0.09, 0.423)	0.138 (0.087, 0.398)	0.188 (0.113, 0.444)	0.184 (0.097, 0.423)
	Taxel_therapies	count					2	2	2	2					2	2	2	2
		time					24 (19, 28)	24 (19, 28)	24 (19, 28)	24 (19, 28)					24 (19, 28)	24 (19, 28)	24 (19, 28)	24 (19, 28)
		n					6 (4, 7)	6 (4, 9)	4 (2, 6)	1 (0, 2)					2 (1, 4)	0 (0, 1)	4 (3, 6)	2 (2, 2)
		post_p					0.31 (0.27, 0.35)	0.45 (0.41, 0.48)	0.23 (0.08, 0.38)	0.44 (0.44, 0.44)					0.43 (0.38, 0.48)	0.48 (0.48, 0.48)	0.34 (0.26, 0.42)	0.42 (0.4, 0.45)
		r_prob					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate					0.206 (0.166, 0.245)	0.093 (0.084, 0.101)	0.384 (0.343, 0.425)	0.189 (0.189, 0.189)					0.303 (0.176, 0.43)	0.143 (0.143, 0.143)	0.23 (0.21, 0.25)	0.113 (0.113, 0.113)
	Carboplatin	count					81	81	81	81					81	81	81	81
		time					22 (14, 31)	22 (14, 31)	22 (14, 31)	22 (14, 31)					22 (14, 31)	22 (14, 31)	22 (14, 31)	22 (14, 31)
		n					6 (2, 11)	5 (3, 11)	4 (1, 7)	4 (2, 6)					4 (1, 8)	4 (1, 6)	3 (1, 7)	4 (2, 7)
		post_p					0.36 (0.17, 0.49)	0.3 (0.1, 0.44)	0.38 (0.2, 0.48)	0.37 (0.21, 0.48)					0.42 (0.27, 0.48)	0.37 (0.17, 0.48)	0.4 (0.23, 0.49)	0.37 (0.19, 0.48)
		r_prob					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate					0.152 (0.096, 0.287)	0.145 (0.082, 0.443)	0.166 (0.093, 0.401)	0.15 (0.072, 0.37)					0.143 (0.09, 0.312)	0.15 (0.085, 0.444)	0.156 (0.093, 0.465)	0.136 (0.077, 0.349)
	Niraparib	count					67	67	67	67					67	67	67	67
		time					20 (14, 32)	20 (14, 32)	20 (14, 32)	20 (14, 32)					20 (14, 32)	20 (14, 32)	20 (14, 32)	20 (14, 32)
		n					6 (3, 13)	5 (3, 11)	4 (2, 7)	4 (1, 8)					3 (1, 6)	4 (2, 7)	4 (2, 7)	3 (1, 7)
		post_p					0.37 (0.19, 0.48)	0.34 (0.15, 0.47)	0.41 (0.32, 0.49)	0.34 (0.18, 0.49)					0.39 (0.2, 0.48)	0.36 (0.21, 0.46)	0.37 (0.21, 0.47)	0.37 (0.19, 0.48)
		r_prob					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate					0.141 (0.098, 0.256)	0.134 (0.08, 0.276)	0.165 (0.091, 0.376)	0.148 (0.072, 0.35)					0.177 (0.105, 0.853)	0.148 (0.078, 0.342)	0.171 (0.117, 0.375)	0.163 (0.085, 0.301)
TEfus+	Hormone_therapies	count		218		218		218		218		218		218		218		218
		time		26 (16, 35)		26 (16, 35)		26 (16, 35)		26 (16, 35)		26 (16, 35)		26 (16, 35)		26 (16, 35)		26 (16, 35)
		n		6 (3, 12)		9 (5, 23)		5 (1, 15)		4 (1, 8)		4 (2, 9)		4 (2, 9)		4 (1, 9)		3 (1, 9)
		post_p		0.29 (0.12, 0.46)		0.24 (0.08, 0.45)		0.35 (0.15, 0.47)		0.38 (0.22, 0.47)		0.34 (0.16, 0.47)		0.31 (0.16, 0.46)		0.39 (0.18, 0.48)		0.38 (0.19, 0.48)
		r_prob		0.35 (0.35, 0.35)		0.18 (0.18, 0.18)		0 (0, 0)		0 (0, 0)		0.18 (0.18, 0.18)		0.12 (0.12, 0.12)		0 (0, 0)		0 (0, 0)
		rate		0.13 (0.086, 0.284)		0.12 (0.083, 0.22)		0.138 (0.077, 0.335)		0.152 (0.087, 0.545)		0.139 (0.079, 0.342)		0.148 (0.085, 0.344)		0.141 (0.088, 0.367)		0.153 (0.083, 0.458)
	Carboplatin	count		239		239		239		239		239		239		239		239
		time		26 (16, 34)		26 (16, 34)		26 (16, 34)		26 (16, 34)		26 (16, 34)		26 (16, 34)		26 (16, 34)		26 (16, 34)
		n		5 (2, 12)		8 (3, 22)		6 (3, 15)		4 (2, 8)		4 (2, 11)		4 (2, 10)		4 (2, 8)		4 (2, 8)
		post_p		0.36 (0.16, 0.47)		0.25 (0.08, 0.45)		0.3 (0.11, 0.47)		0.35 (0.18, 0.48)		0.38 (0.17, 0.48)		0.33 (0.18, 0.48)		0.37 (0.2, 0.47)		0.38 (0.18, 0.48)
		r_prob		0 (0, 0)		0 (0, 0)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0 (0, 0)		0.06 (0.06, 0.06)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
		rate		0.136 (0.082, 0.337)		0.126 (0.086, 0.249)		0.13 (0.079, 0.34)		0.149 (0.083, 0.381)		0.137 (0.083, 0.382)		0.14 (0.08, 0.319)		0.138 (0.08, 0.35)		0.133 (0.078, 0.338)
	Niraparib	count		227		227		227		227		227		227		227		227
		time		26 (17, 35)		26 (17, 35)		26 (17, 35)		26 (17, 35)		26 (17, 35)		26 (17, 35)		26 (17, 35)		26 (17, 35)
		n		5 (2, 12)		8 (4, 25)		6 (3, 14)		4 (2, 9)		5 (2, 10)		5 (2, 12)		4 (2, 9)		4 (2, 8)
		post_p		0.33 (0.14, 0.47)		0.25 (0.08, 0.45)		0.29 (0.12, 0.47)		0.35 (0.18, 0.49)		0.35 (0.16, 0.48)		0.33 (0.17, 0.46)		0.36 (0.2, 0.47)		0.34 (0.14, 0.46)
		r_prob		0 (0, 0)		0 (0, 0)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0 (0, 0)		0.06 (0.06, 0.06)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
		rate		0.138 (0.08, 0.378)		0.123 (0.086, 0.233)		0.127 (0.081, 0.247)		0.129 (0.077, 0.356)		0.134 (0.078, 0.371)		0.133 (0.083, 0.429)		0.132 (0.089, 0.312)		0.147 (0.08, 0.336)