Setting description

Taxel therapies more effective in the TEfus+ biomarker signature

Simulations setting

Survival curves (by signature)


PFS distributions (by signature)


Treatment effects (by signature)

signature var Other Hormone_therapies Taxel_therapies Carboplatin Niraparib
all param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.084, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 11.6, median = 8.4 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1.32, hr = 0.75 af = 1, hr = 1 af = 1, hr = 1
TP53- & AR- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.093, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 10.5, median = 7.6 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1.2, hr = 0.83 af = 1, hr = 1 af = 1, hr = 1
TP53+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.079, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 12.4, median = 8.9 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1.42, hr = 0.69 af = 1, hr = 1 af = 1, hr = 1
DRD+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.075, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 13.1, median = 9.4 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1.49, hr = 0.66 af = 1, hr = 1 af = 1, hr = 1
TEfus+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 1, hr = 1 af = 1, hr = 1



Survival curves (by subgroup)


PFS distributions (by subgroup)


Treatment effects (by subgroup)

subtype var Other Hormone_therapies Taxel_therapies Carboplatin Niraparib
—- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
—+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 1, hr = 1 af = 1, hr = 1
–+- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
–++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 1, hr = 1 af = 1, hr = 1
-+– param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
-+-+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 1, hr = 1 af = 1, hr = 1
-++- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
-+++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 1, hr = 1 af = 1, hr = 1
+— param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+–+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 1, hr = 1 af = 1, hr = 1
+-+- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+-++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 1, hr = 1 af = 1, hr = 1
++– param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
++-+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 1, hr = 1 af = 1, hr = 1
+++- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
++++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 1, hr = 1 af = 1, hr = 1

Errors and power


graduation (counts and proportions):
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 4 20 1 0
TP53- & AR- 30 115 9 6
TP53+ 4 36 3 1
DRD+ 0 32 0 0
TEfus+ 1 325 0 0
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 0.008 0.040 0.002 0.000
TP53- & AR- 0.060 0.230 0.018 0.012
TP53+ 0.008 0.072 0.006 0.002
DRD+ 0.000 0.064 0.000 0.000
TEfus+ 0.002 0.650 0.000 0.000
futility (counts and proportions):
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 15 0 6 4
TP53- & AR- 244 6 221 208
TP53+ 74 1 79 77
DRD+ 41 2 81 67
TEfus+ 218 0 239 227
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 0.030 0.000 0.012 0.008
TP53- & AR- 0.488 0.012 0.442 0.416
TP53+ 0.148 0.002 0.158 0.154
DRD+ 0.082 0.004 0.162 0.134
TEfus+ 0.436 0.000 0.478 0.454
max sample size (counts and proportions):
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 0 0 0 0
TP53- & AR- 16 16 12 13
TP53+ 6 31 2 22
DRD+ 0 0 0 0
TEfus+ 0 21 3 2
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 0.000 0.000 0.000 0.000
TP53- & AR- 0.032 0.032 0.024 0.026
TP53+ 0.012 0.062 0.004 0.044
DRD+ 0.000 0.000 0.000 0.000
TEfus+ 0.000 0.042 0.006 0.004


Errors & power

The overall error was 0.228.
The corresponding errors separate for the different treatments were:

Hormone_therapies   Taxel_therapies       Carboplatin         Niraparib 
            0.078             0.124             0.026             0.014 

The overall power was 0.65.
The corresponding power separate for the different treatments were:

Hormone_therapies   Taxel_therapies       Carboplatin         Niraparib 
             0.00              0.65              0.00              0.00 

Median results at the end of the trial

By signature:
signature var Control Hormone_therapies Taxel_therapies Carboplatin Niraparib
all graduation 0 4 20 1 0
futility 0 15 0 6 4
max_n 0 0 0 0 0
n 422 (388, 454) 174 (115, 245) 189 (114, 275) 174 (120, 247) 180 (119, 255)
n_unique 388 (359, 418) 160 (105, 228) 174 (104, 257) 158 (109, 228) 164 (110, 241)
time_trial 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36)
time_stop NA (NA, NA) 5 (3, 31) 6 (5, 23) 22 (7, 34) 28 (22, 30)
post_p NA (NA, NA) 0.06 (0, 0.39) 1 (0.95, 1) 0.07 (0, 0.37) 0.07 (0, 0.37)
rate 0.096 (0.089, 0.104) 0.112 (0.102, 0.129) 0.067 (0.057, 0.081) 0.113 (0.102, 0.128) 0.112 (0.101, 0.127)
TP53- & AR- graduation 0 30 115 9 6
futility 0 244 6 221 208
max_n 0 16 16 12 13
n 174 (149, 198) 62 (27, 129) 64 (27, 121) 65 (27, 121) 66 (27, 129)
n_unique 161 (137, 183) 56 (25, 121) 57 (25, 114) 60 (25, 114) 61 (26, 121)
time_trial 36 (36, 36) 32 (10, 36) 36 (13, 36) 36 (16, 36) 36 (16, 36)
time_stop NA (NA, NA) 17 (8, 31) 15 (10, 29) 21 (13, 32) 21 (13, 33)
post_p NA (NA, NA) 0.24 (0.03, 0.7) 0.94 (0.55, 1) 0.24 (0.03, 0.68) 0.24 (0.04, 0.73)
rate 0.101 (0.091, 0.113) 0.115 (0.097, 0.145) 0.078 (0.058, 0.099) 0.115 (0.098, 0.146) 0.113 (0.095, 0.144)
TP53+ graduation 0 4 36 3 1
futility 0 74 1 79 77
max_n 0 6 31 2 22
n 188 (166, 210) 80 (45, 120) 92 (45, 139) 78 (43, 115) 80 (46, 124)
n_unique 173 (152, 194) 73 (40, 112) 85 (40, 130) 71 (38, 107) 73 (42, 114)
time_trial 36 (36, 36) 36 (29, 36) 36 (36, 36) 36 (25, 36) 36 (27, 36)
time_stop NA (NA, NA) 24 (13, 33) 14 (9, 27) 22 (13, 32) 23 (13, 34)
post_p NA (NA, NA) 0.11 (0.01, 0.56) 1 (0.85, 1) 0.1 (0.01, 0.47) 0.11 (0.01, 0.47)
rate 0.093 (0.083, 0.104) 0.113 (0.097, 0.135) 0.061 (0.048, 0.078) 0.114 (0.097, 0.138) 0.113 (0.097, 0.135)
DRD+ graduation 0 0 32 0 0
futility 0 41 2 81 67
max_n 0 0 0 0 0
n 113 (98, 130) 48 (26, 71) 46 (25, 78) 56 (34, 80) 58 (35, 82)
n_unique 103 (89, 119) 44 (23, 64) 41 (22, 72) 51 (32, 73) 53 (33, 76)
time_trial 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (24, 36) 36 (28, 36)
time_stop NA (NA, NA) 28 (19, 35) 20 (16, 30) 22 (14, 31) 20 (14, 32)
post_p NA (NA, NA) 0.19 (0.02, 0.58) 0.96 (0.61, 1) 0.14 (0.01, 0.53) 0.14 (0.02, 0.55)
rate 0.092 (0.079, 0.107) 0.112 (0.092, 0.143) 0.064 (0.045, 0.086) 0.114 (0.096, 0.142) 0.113 (0.094, 0.138)
TEfus+ graduation 0 1 325 0 0
futility 0 218 0 239 227
max_n 0 0 21 3 2
n 159 (139, 179) 55 (27, 93) 82 (28, 138) 58 (31, 98) 58 (34, 104)
n_unique 146 (126, 164) 49 (25, 86) 76 (26, 128) 52 (28, 91) 53 (31, 96)
time_trial 36 (36, 36) 36 (19, 36) 26 (11, 36) 36 (18, 36) 36 (19, 36)
time_stop NA (NA, NA) 25 (16, 35) 18 (10, 31) 26 (16, 34) 26 (17, 35)
post_p NA (NA, NA) 0.02 (0, 0.19) 1 (1, 1) 0.01 (0, 0.12) 0.01 (0, 0.13)
rate 0.074 (0.066, 0.086) 0.115 (0.093, 0.148) 0.036 (0.028, 0.044) 0.114 (0.096, 0.14) 0.113 (0.095, 0.139)


By subgroup combinations:
subtype var Control Hormone_therapies Taxel_therapies Carboplatin Niraparib
—- graduation 0 287 139 233 215
futility 0 0 0 0 0
max_n 0 16 16 12 13
n 111 (89, 130) 36 (17, 95) 31 (11, 88) 35 (10, 88) 34 (10, 91)
n_unique 104 (83, 122) 33 (16, 91) 29 (10, 83) 32 (9, 83) 31 (9, 86)
post_p NA (NA, NA) 0.47 (0.11, 0.86) 0.47 (0.1, 0.9) 0.43 (0.11, 0.86) 0.45 (0.1, 0.86)
rate 0.113 (0.099, 0.127) 0.116 (0.096, 0.156) 0.114 (0.089, 0.171) 0.118 (0.095, 0.182) 0.117 (0.092, 0.184)
—+ graduation 0 377 372 352 329
futility 0 0 0 0 0
max_n 0 13 34 15 12
n 21 (14, 29) 6 (2, 16) 9 (3, 22) 6 (2, 17) 6 (2, 18)
n_unique 19 (12, 26) 5 (2, 15) 8 (2, 20) 5 (2, 16) 6 (2, 17)
post_p NA (NA, NA) 0.27 (0.11, 0.56) 0.9 (0.57, 0.99) 0.27 (0.11, 0.54) 0.28 (0.11, 0.55)
rate 0.075 (0.052, 0.108) 0.125 (0.075, 0.268) 0.036 (0.02, 0.071) 0.129 (0.077, 0.286) 0.124 (0.075, 0.342)
–+- graduation 0 92 56 85 78
futility 0 0 0 0 0
max_n 0 6 31 2 22
n 62 (50, 76) 26 (9, 57) 22 (7, 51) 24 (7, 55) 25 (8, 55)
n_unique 57 (45, 71) 25 (9, 54) 20 (6, 48) 22 (6, 52) 23 (7, 52)
post_p NA (NA, NA) 0.44 (0.13, 0.9) 0.46 (0.1, 0.85) 0.46 (0.12, 0.88) 0.44 (0.1, 0.89)
rate 0.113 (0.094, 0.137) 0.118 (0.091, 0.18) 0.12 (0.089, 0.216) 0.119 (0.09, 0.213) 0.12 (0.088, 0.206)
–++ graduation 0 260 342 277 257
futility 0 0 0 0 0
max_n 0 5 43 5 19
n 46 (34, 56) 10 (5, 30) 25 (10, 49) 10 (4, 32) 10 (4, 31)
n_unique 42 (31, 52) 9 (4, 28) 23 (9, 45) 9 (3, 30) 9 (4, 29)
post_p NA (NA, NA) 0.18 (0.05, 0.45) 0.99 (0.87, 1) 0.18 (0.05, 0.45) 0.19 (0.06, 0.46)
rate 0.075 (0.057, 0.095) 0.12 (0.083, 0.22) 0.036 (0.024, 0.052) 0.122 (0.086, 0.238) 0.121 (0.085, 0.215)
-+– graduation 0 293 161 261 243
futility 0 0 0 0 0
max_n 0 14 16 12 13
n 21 (14, 28) 6 (1, 18) 7 (2, 19) 9 (3, 21) 9 (3, 21)
n_unique 19 (13, 26) 5 (1, 17) 6 (2, 17) 8 (3, 19) 8 (3, 20)
post_p NA (NA, NA) 0.46 (0.22, 0.82) 0.49 (0.17, 0.83) 0.45 (0.18, 0.82) 0.46 (0.19, 0.83)
rate 0.115 (0.084, 0.157) 0.133 (0.074, 0.371) 0.123 (0.072, 0.275) 0.128 (0.082, 0.248) 0.123 (0.081, 0.251)
-+-+ graduation 0 380 380 359 344
futility 0 0 0 0 0
max_n 0 12 34 15 12
n 21 (14, 27) 5 (1, 17) 6 (1, 20) 7 (3, 20) 7 (3, 19)
n_unique 19 (12, 26) 4 (1, 16) 6 (1, 18) 7 (3, 18) 6 (3, 17)
post_p NA (NA, NA) 0.3 (0.12, 0.59) 0.88 (0.55, 0.99) 0.25 (0.1, 0.54) 0.26 (0.09, 0.54)
rate 0.075 (0.052, 0.108) 0.125 (0.071, 0.299) 0.034 (0.015, 0.072) 0.123 (0.077, 0.274) 0.123 (0.077, 0.238)
-++- graduation 0 111 85 140 119
futility 0 0 0 0 0
max_n 0 6 31 2 22
n 11 (7, 17) 5 (1, 11) 4 (1, 10) 5 (2, 12) 6 (2, 12)
n_unique 10 (6, 15) 4 (1, 10) 4 (1, 9) 5 (2, 11) 5 (2, 11)
post_p NA (NA, NA) 0.47 (0.23, 0.78) 0.46 (0.22, 0.78) 0.46 (0.22, 0.81) 0.46 (0.24, 0.8)
rate 0.116 (0.073, 0.174) 0.123 (0.071, 0.374) 0.128 (0.068, 0.401) 0.129 (0.071, 0.318) 0.124 (0.072, 0.324)
-+++ graduation 0 270 355 296 273
futility 0 0 0 0 0
max_n 0 5 43 5 19
n 12 (7, 17) 4 (1, 12) 4 (1, 12) 5 (2, 11) 6 (2, 11)
n_unique 11 (6, 16) 4 (1, 11) 4 (0, 11) 4 (2, 10) 5 (2, 11)
post_p NA (NA, NA) 0.35 (0.17, 0.61) 0.8 (0.46, 0.97) 0.34 (0.16, 0.61) 0.34 (0.15, 0.64)
rate 0.077 (0.047, 0.133) 0.126 (0.067, 0.398) 0.036 (0.005, 0.101) 0.131 (0.072, 0.288) 0.12 (0.065, 0.27)
+— graduation 0 19 20 7 4
futility 0 0 0 0 0
max_n 0 0 0 0 0
n 19 (13, 26) 8 (3, 18) 11 (4, 21) 8 (3, 18) 8 (3, 17)
n_unique 18 (12, 24) 8 (3, 16) 9 (4, 18) 8 (3, 16) 7 (3, 16)
post_p NA (NA, NA) 0.44 (0.16, 0.8) 0.47 (0.18, 0.83) 0.48 (0.18, 0.85) 0.46 (0.2, 0.83)
rate 0.116 (0.082, 0.162) 0.131 (0.082, 0.302) 0.12 (0.082, 0.238) 0.123 (0.075, 0.286) 0.126 (0.076, 0.295)
+–+ graduation 0 233 338 241 227
futility 0 0 0 0 0
max_n 0 0 21 3 2
n 17 (11, 23) 6 (2, 13) 9 (3, 18) 6 (2, 13) 6 (2, 13)
n_unique 15 (10, 22) 5 (2, 12) 8 (3, 17) 5 (2, 12) 5 (2, 12)
post_p NA (NA, NA) 0.3 (0.14, 0.57) 0.88 (0.56, 0.98) 0.32 (0.13, 0.58) 0.3 (0.12, 0.61)
rate 0.075 (0.047, 0.114) 0.127 (0.073, 0.319) 0.038 (0.018, 0.071) 0.122 (0.07, 0.319) 0.128 (0.071, 0.309)
+-+- graduation 0 92 56 85 78
futility 0 0 0 0 0
max_n 0 6 31 2 22
n 16 (10, 22) 7 (2, 14) 8 (3, 16) 6 (2, 14) 7 (2, 15)
n_unique 14 (9, 20) 6 (2, 13) 7 (3, 15) 6 (2, 13) 6 (2, 14)
post_p NA (NA, NA) 0.45 (0.2, 0.8) 0.47 (0.18, 0.82) 0.43 (0.19, 0.8) 0.44 (0.22, 0.8)
rate 0.113 (0.075, 0.163) 0.127 (0.074, 0.306) 0.121 (0.073, 0.243) 0.132 (0.074, 0.312) 0.126 (0.073, 0.302)
+-++ graduation 0 260 342 277 257
futility 0 0 0 0 0
max_n 0 5 43 5 19
n 17 (11, 23) 6 (2, 13) 8 (2, 18) 5 (2, 13) 6 (2, 15)
n_unique 15 (10, 22) 5 (2, 12) 8 (2, 16) 5 (2, 11) 5 (2, 14)
post_p NA (NA, NA) 0.29 (0.13, 0.57) 0.89 (0.55, 0.99) 0.3 (0.13, 0.54) 0.3 (0.13, 0.57)
rate 0.074 (0.048, 0.115) 0.128 (0.073, 0.293) 0.035 (0.017, 0.072) 0.13 (0.072, 0.287) 0.125 (0.071, 0.357)
++– graduation 0 55 53 83 68
futility 0 0 0 0 0
max_n 0 0 0 0 0
n 11 (7, 16) 5 (2, 10) 4 (1, 10) 6 (2, 12) 5 (2, 12)
n_unique 10 (6, 15) 5 (1, 10) 4 (1, 9) 5 (2, 11) 5 (2, 11)
post_p NA (NA, NA) 0.47 (0.22, 0.83) 0.45 (0.21, 0.76) 0.48 (0.23, 0.81) 0.45 (0.21, 0.81)
rate 0.114 (0.073, 0.185) 0.129 (0.059, 0.348) 0.129 (0.073, 0.375) 0.126 (0.069, 0.289) 0.128 (0.07, 0.377)
++-+ graduation 0 245 352 265 252
futility 0 0 0 0 0
max_n 0 0 21 3 2
n 12 (7, 18) 5 (1, 11) 4 (0, 11) 5 (2, 11) 5 (2, 12)
n_unique 11 (7, 17) 4 (1, 10) 4 (0, 10) 5 (2, 10) 5 (2, 11)
post_p NA (NA, NA) 0.35 (0.16, 0.61) 0.78 (0.47, 0.96) 0.32 (0.14, 0.57) 0.32 (0.14, 0.62)
rate 0.076 (0.046, 0.122) 0.121 (0.066, 0.321) 0.036 (0, 0.113) 0.131 (0.072, 0.331) 0.126 (0.073, 0.297)
+++- graduation 0 111 85 140 119
futility 0 0 0 0 0
max_n 0 6 31 2 22
n 11 (7, 17) 5 (2, 11) 5 (1, 10) 5 (2, 12) 6 (2, 13)
n_unique 10 (6, 15) 4 (1, 11) 4 (1, 9) 5 (2, 11) 6 (2, 12)
post_p NA (NA, NA) 0.49 (0.24, 0.81) 0.46 (0.22, 0.77) 0.46 (0.23, 0.79) 0.48 (0.22, 0.82)
rate 0.118 (0.073, 0.191) 0.124 (0.068, 0.357) 0.131 (0.069, 0.331) 0.131 (0.072, 0.36) 0.122 (0.07, 0.289)
++++ graduation 0 270 355 296 273
futility 0 0 0 0 0
max_n 0 5 43 5 19
n 12 (8, 17) 4 (1, 11) 4 (0, 12) 5 (2, 12) 5 (2, 11)
n_unique 11 (7, 16) 4 (1, 10) 4 (0, 11) 4 (2, 11) 4 (2, 10)
post_p NA (NA, NA) 0.35 (0.15, 0.62) 0.81 (0.48, 0.95) 0.34 (0.17, 0.59) 0.32 (0.14, 0.59)
rate 0.076 (0.044, 0.131) 0.129 (0.065, 0.373) 0.035 (0.008, 0.091) 0.119 (0.071, 0.296) 0.125 (0.073, 0.308)

Median results over time

Signatures:

Posterior probabilities

Randomization probabilities

PFS rates


Subgroup combinations:

Posterior probabilities

Randomization probabilities

PFS rates

Median results at stop

By signature

Graduation:
signature var Hormone_therapies Taxel_therapies Carboplatin Niraparib
all count 4 20 1
time_stop 4 (4, 6) 6 (5, 23) 5 (5, 5)
n_trt 36 (28, 41) 40 (27, 153) 29 (29, 29)
n_control 44 (38, 62) 66 (48, 250) 48 (48, 48)
post_p 0.87 (0.86, 0.89) 0.96 (0.89, 1) 0.92 (0.92, 0.92)
order 1 (1, 1) 1 (1, 1.2) 1 (1, 1)
TP53- & AR- count 30 115 9 6
time_stop 10 (7, 16) 14 (10, 28) 14 (12, 20) 16 (10, 18)
n_trt 32 (26, 45) 32 (25, 71) 36 (31, 44) 32 (27, 42)
n_control 41 (27, 66) 60 (37, 120) 63 (49, 77) 68 (43, 90)
post_p 0.91 (0.85, 0.96) 0.95 (0.88, 1) 0.91 (0.86, 0.96) 0.96 (0.86, 0.99)
order 1 (1, 2) 1 (1, 2) 1 (1, 2) 1 (1, 2)
TP53+ count 4 36 3 1
time_stop 10 (9, 12) 14 (9, 28) 9 (8, 10) 8 (8, 8)
n_trt 28 (25, 35) 45 (27, 101) 29 (27, 32) 31 (31, 31)
n_control 40 (32, 49) 66 (34, 130) 32 (31, 34) 27 (27, 27)
post_p 0.98 (0.92, 0.99) 0.99 (0.95, 1) 0.98 (0.96, 0.98) 0.96 (0.96, 0.96)
order 1 (1, 1.7) 1 (1, 2.5) 2 (1.2, 2) 1 (1, 1)
DRD+ count 32
time_stop 20 (16, 31)
n_trt 29 (25, 47)
n_control 55 (38, 90)
post_p 0.99 (0.92, 1)
order 1.5 (1, 3)
TEfus+ count 1 325
time_stop 11 (11, 11) 18 (10, 31)
n_trt 27 (27, 27) 55 (28, 113)
n_control 47 (47, 47) 67 (37, 137)
post_p 0.87 (0.87, 0.87) 1 (0.97, 1)
order 1 (1, 1) 1 (1, 2)
Futility:
signature var Hormone_therapies Taxel_therapies Carboplatin Niraparib
all count 15 6 4
time_stop 5 (3, 32) 27 (10, 34) 28 (22, 30)
n_trt 31 (26, 121) 94 (40, 180) 101 (79, 127)
n_control 45 (29, 384) 268 (110, 431) 314 (240, 329)
post_p 0.05 (0, 0.26) 0 (0, 0.02) 0.01 (0, 0.02)
order 1 (1, 5.2) 3.5 (1, 6.5) 4.5 (3.3, 7.1)
TP53- & AR- count 244 6 221 208
time_stop 19 (9, 32) 22 (14, 31) 21 (14, 32) 22 (13, 33)
n_trt 40 (26, 91) 36 (28, 78) 38 (26, 86) 39 (25, 87)
n_control 78 (33, 152) 96 (58, 142) 95 (55, 151) 97 (59, 156)
post_p 0.14 (0.03, 0.25) 0.19 (0.04, 0.23) 0.14 (0.05, 0.24) 0.14 (0.04, 0.25)
order 1 (1, 4) 2 (1, 3) 2 (1, 4) 2 (1, 4)
TP53+ count 74 1 79 77
time_stop 25 (13, 33) 11 (11, 11) 23 (13, 32) 23 (13, 34)
n_trt 50 (30, 86) 28 (28, 28) 47 (29, 77) 47 (27, 74)
n_control 114 (57, 172) 40 (40, 40) 106 (58, 175) 109 (54, 172)
post_p 0.03 (0, 0.17) 0.14 (0.14, 0.14) 0.04 (0.01, 0.17) 0.04 (0.01, 0.13)
order 3 (1, 5) 1 (1, 1) 2 (1, 6) 2 (1, 5)
DRD+ count 41 2 81 67
time_stop 28 (19, 35) 24 (19, 28) 22 (14, 31) 20 (14, 32)
n_trt 33 (25, 50) 26 (26, 26) 35 (26, 50) 35 (26, 55)
n_control 87 (57, 111) 58 (40, 76) 57 (32, 99) 56 (33, 102)
post_p 0.03 (0, 0.2) 0.06 (0.02, 0.1) 0.03 (0.01, 0.16) 0.03 (0, 0.16)
order 4 (2, 7) 2 (1.2, 2.8) 3 (1, 5) 3 (1, 6.4)
TEfus+ count 218 239 227
time_stop 26 (16, 35) 26 (16, 34) 26 (17, 35)
n_trt 42 (26, 77) 44 (27, 76) 45 (30, 83)
n_control 102 (58, 155) 105 (52, 152) 106 (64, 155)
post_p 0.01 (0, 0.08) 0.01 (0, 0.09) 0.01 (0, 0.08)
order 3 (1, 5) 3 (1, 5) 3 (1, 5)


By subgroup combinations

Graduation:
signature treatment var —- —+ –+- –++ -+– -+-+ -++- -+++ +— +–+ +-+- +-++ ++– ++-+ +++- ++++
all Hormone_therapies count 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4
time 4 (4, 6) 4 (4, 6) 4 (4, 6) 4 (4, 6) 4 (4, 6) 4 (4, 6) 4 (4, 6) 4 (4, 6) 4 (4, 6) 4 (4, 6) 4 (4, 6) 4 (4, 6) 4 (4, 6) 4 (4, 6) 4 (4, 6) 4 (4, 6)
n 20 (15, 23) 2 (1, 2) 6 (2, 12) 2 (1, 7) 0 (0, 0) 0 (0, 2) 0 (0, 0) 0 (0, 0) 0 (0, 2) 0 (0, 1) 1 (0, 1) 1 (0, 2) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0)
post_p 0.63 (0.57, 0.75) 0.54 (0.53, 0.56) 0.53 (0.51, 0.62) 0.6 (0.55, 0.63) NA (NA, NA) 0.56 (0.56, 0.56) NA (NA, NA) NA (NA, NA) 0.59 (0.55, 0.62) NA (NA, NA) 0.53 (0.52, 0.54) 0.52 (0.52, 0.53) 0.53 (0.53, 0.53) NA (NA, NA) NA (NA, NA) NA (NA, NA)
r_prob 0.44 (0.44, 0.44) 0.35 (0.35, 0.35) 0.33 (0.33, 0.33) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.18 (0.18, 0.18) 0.18 (0.18, 0.18) 0.12 (0.12, 0.12) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.073 (0.04, 0.083) 0 (0, 0) 0.086 (0.023, 0.097) 0 (0, 0) NA (NA, NA) 0.55 (0.11, 0.99) NA (NA, NA) NA (NA, NA) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) NA (NA, NA) NA (NA, NA) NA (NA, NA)
Taxel_therapies count 20 20 20 20 20 20 20 20 20 20 20 20 20 20 20 20
time 6 (5, 23) 6 (5, 23) 6 (5, 23) 6 (5, 23) 6 (5, 23) 6 (5, 23) 6 (5, 23) 6 (5, 23) 6 (5, 23) 6 (5, 23) 6 (5, 23) 6 (5, 23) 6 (5, 23) 6 (5, 23) 6 (5, 23) 6 (5, 23)
n 7 (4, 56) 3 (1, 10) 6 (2, 13) 8 (3, 18) 1 (0, 5) 2 (0, 6) 0 (0, 2) 0 (0, 1) 4 (2, 10) 3 (1, 8) 3 (1, 8) 2 (1, 5) 0 (0, 5) 1 (0, 3) 1 (0, 5) 0 (0, 2)
post_p 0.62 (0.55, 0.76) 0.61 (0.54, 0.74) 0.6 (0.53, 0.73) 0.61 (0.56, 0.77) 0.58 (0.5, 0.66) 0.56 (0.52, 0.93) 0.54 (0.51, 0.61) 0.58 (0.53, 0.82) 0.56 (0.51, 0.64) 0.55 (0.5, 0.76) 0.55 (0.51, 0.68) 0.56 (0.51, 0.77) 0.55 (0.53, 0.8) 0.55 (0.52, 0.88) 0.53 (0.51, 0.6) 0.56 (0.51, 0.71)
r_prob 0.11 (0.11, 0.11) 0.29 (0.29, 0.29) 0.17 (0.17, 0.17) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.41 (0.41, 0.41) 0.41 (0.41, 0.41) 0.37 (0.37, 0.37) 0.37 (0.37, 0.37) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.065 (0, 0.098) 0 (0, 0.051) 0.015 (0, 0.116) 0.023 (0, 0.067) 0 (0, 0.089) 0 (0, 0.056) 0 (0, 0.149) 0 (0, 0.015) 0.051 (0, 0.148) 0 (0, 0.075) 0.06 (0, 0.142) 0 (0, 0.028) 0 (0, 0.119) 0 (0, 0.025) 0 (0, 0.157) 0 (0, 0.013)
Carboplatin count 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
time 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5)
n 1 (1, 1) 0 (0, 0) 8 (8, 8) 1 (1, 1) 2 (2, 2) 3 (3, 3) 3 (3, 3) 2 (2, 2) 0 (0, 0) 0 (0, 0) 0 (0, 0) 2 (2, 2) 2 (2, 2) 1 (1, 1) 2 (2, 2) 2 (2, 2)
post_p 0.55 (0.55, 0.55) NA (NA, NA) 0.89 (0.89, 0.89) 0.51 (0.51, 0.51) 0.52 (0.52, 0.52) 0.55 (0.55, 0.55) 0.56 (0.56, 0.56) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.56 (0.56, 0.56) NA (NA, NA) 0.54 (0.54, 0.54) 0.5 (0.5, 0.5) 0.51 (0.51, 0.51)
r_prob 0 (0, 0) 0 (0, 0) 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0 (0, 0) NA (NA, NA) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0 (0, 0) 0.173 (0.173, 0.173) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53- & AR- Hormone_therapies count 30 30 30 30
time 10 (7, 16) 10 (7, 16) 10 (7, 16) 10 (7, 16)
n 26 (19, 39) 4 (1, 5) 2 (0, 4) 2 (0, 4)
post_p 0.83 (0.73, 0.9) 0.55 (0.51, 0.69) 0.59 (0.54, 0.73) 0.57 (0.52, 0.65)
r_prob 0.44 (0.44, 0.44) 0.35 (0.35, 0.35) 0 (0, 0) 0 (0, 0)
rate 0.078 (0.054, 0.106) 0.066 (0, 0.144) 0 (0, 0.093) 0 (0, 0.068)
Taxel_therapies count 115 115 115 115
time 14 (10, 28) 14 (10, 28) 14 (10, 28) 14 (10, 28)
n 21 (15, 48) 5 (2, 13) 4 (0, 9) 3 (1, 10)
post_p 0.8 (0.72, 0.93) 0.73 (0.54, 0.92) 0.62 (0.51, 0.81) 0.68 (0.54, 0.85)
r_prob 0.11 (0.11, 0.11) 0.29 (0.29, 0.29) 0 (0, 0) 0 (0, 0)
rate 0.083 (0.048, 0.105) 0.026 (0, 0.07) 0.06 (0, 0.134) 0 (0, 0.057)
Carboplatin count 9 9 9 9
time 14 (12, 20) 14 (12, 20) 14 (12, 20) 14 (12, 20)
n 19 (17, 28) 4 (2, 4) 5 (2, 10) 5 (3, 7)
post_p 0.86 (0.75, 0.93) 0.54 (0.52, 0.65) 0.7 (0.53, 0.81) 0.54 (0.51, 0.77)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.071 (0.055, 0.11) 0.038 (0, 0.084) 0.093 (0.062, 0.155) 0.06 (0.025, 0.071)
Niraparib count 6 6 6 6
time 16 (10, 18) 16 (10, 18) 16 (10, 18) 16 (10, 18)
n 18 (16, 25) 3 (2, 3) 4 (4, 7) 5 (4, 10)
post_p 0.84 (0.74, 0.93) 0.56 (0.51, 0.67) 0.83 (0.57, 0.88) 0.68 (0.53, 0.77)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.059 (0.041, 0.091) 0.066 (0, 0.116) 0.04 (0.016, 0.087) 0.064 (0.028, 0.103)
TP53+ Hormone_therapies count 4 4 4 4 4 4 4 4
time 10 (9, 12) 10 (9, 12) 10 (9, 12) 10 (9, 12) 10 (9, 12) 10 (9, 12) 10 (9, 12) 10 (9, 12)
n 18 (13, 20) 6 (3, 7) 0 (0, 2) 1 (0, 2) 2 (1, 3) 1 (0, 1) 2 (0, 3) 0 (0, 2)
post_p 0.88 (0.78, 0.92) 0.72 (0.67, 0.75) 0.53 (0.53, 0.54) 0.53 (0.52, 0.54) 0.58 (0.53, 0.68) 0.53 (0.52, 0.53) 0.6 (0.54, 0.67) NA (NA, NA)
r_prob 0.33 (0.33, 0.33) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0.12 (0.12, 0.12) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0)
rate 0.056 (0.035, 0.074) 0 (0, 0) 0.081 (0.016, 0.146) 0 (0, 0) 0.038 (0, 0.103) 0 (0, 0) 0 (0, 0) 0.044 (0.009, 0.079)
Taxel_therapies count 36 36 36 36 36 36 36 36
time 14 (9, 28) 14 (9, 28) 14 (9, 28) 14 (9, 28) 14 (9, 28) 14 (9, 28) 14 (9, 28) 14 (9, 28)
n 16 (8, 35) 14 (6, 36) 2 (0, 5) 2 (0, 6) 4 (2, 10) 4 (1, 12) 2 (0, 5) 2 (0, 6)
post_p 0.77 (0.7, 0.85) 0.82 (0.69, 0.99) 0.55 (0.52, 0.7) 0.6 (0.53, 0.9) 0.62 (0.51, 0.86) 0.64 (0.51, 0.84) 0.56 (0.52, 0.75) 0.68 (0.52, 0.84)
r_prob 0.17 (0.17, 0.17) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0) 0.37 (0.37, 0.37) 0.37 (0.37, 0.37) 0 (0, 0) 0 (0, 0)
rate 0.071 (0.041, 0.102) 0.03 (0.012, 0.054) 0.069 (0, 0.119) 0 (0, 0.042) 0.071 (0.013, 0.12) 0.031 (0, 0.078) 0.083 (0, 0.126) 0 (0, 0.067)
Carboplatin count 3 3 3 3 3 3 3 3
time 9 (8, 10) 9 (8, 10) 9 (8, 10) 9 (8, 10) 9 (8, 10) 9 (8, 10) 9 (8, 10) 9 (8, 10)
n 12 (12, 13) 2 (1, 4) 2 (1, 4) 2 (1, 4) 1 (0, 2) 3 (2, 3) 2 (1, 3) 4 (2, 5)
post_p 0.79 (0.74, 0.85) 0.59 (0.55, 0.6) 0.58 (0.57, 0.66) 0.55 (0.53, 0.58) 0.55 (0.54, 0.57) 0.58 (0.56, 0.6) 0.54 (0.51, 0.56) 0.54 (0.52, 0.56)
r_prob 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.054 (0.027, 0.058) 0 (0, 0.039) 0 (0, 0) 0 (0, 0.078) 0.066 (0.013, 0.119) 0 (0, 0) 0.088 (0.018, 0.155) 0 (0, 0.039)
Niraparib count 1 1 1 1 1 1 1 1
time 8 (8, 8) 8 (8, 8) 8 (8, 8) 8 (8, 8) 8 (8, 8) 8 (8, 8) 8 (8, 8) 8 (8, 8)
n 11 (11, 11) 2 (2, 2) 4 (4, 4) 3 (3, 3) 2 (2, 2) 2 (2, 2) 4 (4, 4) 3 (3, 3)
post_p 0.79 (0.79, 0.79) 0.53 (0.53, 0.53) 0.52 (0.52, 0.52) 0.51 (0.51, 0.51) 0.61 (0.61, 0.61) 0.54 (0.54, 0.54) 0.57 (0.57, 0.57) 0.59 (0.59, 0.59)
r_prob 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.031 (0.031, 0.031) 0 (0, 0) 0.053 (0.053, 0.053) 0.067 (0.067, 0.067) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
DRD+ Taxel_therapies count 32 32 32 32 32 32 32 32
time 20 (16, 31) 20 (16, 31) 20 (16, 31) 20 (16, 31) 20 (16, 31) 20 (16, 31) 20 (16, 31) 20 (16, 31)
n 4 (1, 15) 6 (3, 11) 4 (0, 7) 3 (0, 7) 2 (1, 5) 2 (1, 8) 4 (0, 7) 4 (0, 6)
post_p 0.62 (0.54, 0.79) 0.83 (0.59, 0.95) 0.64 (0.53, 0.77) 0.68 (0.53, 0.88) 0.57 (0.52, 0.82) 0.69 (0.54, 0.89) 0.64 (0.52, 0.86) 0.64 (0.53, 0.82)
r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.076 (0, 0.107) 0.027 (0, 0.057) 0.074 (0.017, 0.129) 0.025 (0, 0.077) 0.083 (0, 0.153) 0.004 (0, 0.065) 0.059 (0, 0.154) 0.035 (0, 0.076)
TEfus+ Hormone_therapies count 1 1 1 1 1 1 1 1
time 11 (11, 11) 11 (11, 11) 11 (11, 11) 11 (11, 11) 11 (11, 11) 11 (11, 11) 11 (11, 11) 11 (11, 11)
n 5 (5, 5) 7 (7, 7) 4 (4, 4) 3 (3, 3) 0 (0, 0) 3 (3, 3) 3 (3, 3) 2 (2, 2)
post_p 0.67 (0.67, 0.67) 0.79 (0.79, 0.79) 0.51 (0.51, 0.51) 0.54 (0.54, 0.54) NA (NA, NA) 0.52 (0.52, 0.52) 0.51 (0.51, 0.51) 0.63 (0.63, 0.63)
r_prob 0.35 (0.35, 0.35) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0.18 (0.18, 0.18) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0)
rate 0 (0, 0) 0.032 (0.032, 0.032) 0.08 (0.08, 0.08) 0.087 (0.087, 0.087) NA (NA, NA) 0.092 (0.092, 0.092) 0.133 (0.133, 0.133) 0 (0, 0)
Taxel_therapies count 325 325 325 325 325 325 325 325
time 18 (10, 31) 18 (10, 31) 18 (10, 31) 18 (10, 31) 18 (10, 31) 18 (10, 31) 18 (10, 31) 18 (10, 31)
n 7 (2, 17) 19 (10, 37) 5 (1, 14) 3 (0, 10) 7 (3, 15) 6 (2, 15) 3 (0, 9) 3 (0, 9)
post_p 0.75 (0.55, 0.95) 0.9 (0.73, 0.99) 0.72 (0.54, 0.94) 0.66 (0.53, 0.93) 0.74 (0.55, 0.94) 0.74 (0.54, 0.95) 0.66 (0.53, 0.89) 0.65 (0.53, 0.89)
r_prob 0.29 (0.29, 0.29) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0) 0.41 (0.41, 0.41) 0.37 (0.37, 0.37) 0 (0, 0) 0 (0, 0)
rate 0.033 (0, 0.067) 0.035 (0.014, 0.054) 0.025 (0, 0.067) 0.012 (0, 0.068) 0.033 (0, 0.062) 0.028 (0, 0.063) 0.003 (0, 0.074) 0.007 (0, 0.068)
Futility:
signature treatment var —- —+ –+- –++ -+– -+-+ -++- -+++ +— +–+ +-+- +-++ ++– ++-+ +++- ++++
all Hormone_therapies count 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15 15
time 5 (3, 32) 5 (3, 32) 5 (3, 32) 5 (3, 32) 5 (3, 32) 5 (3, 32) 5 (3, 32) 5 (3, 32) 5 (3, 32) 5 (3, 32) 5 (3, 32) 5 (3, 32) 5 (3, 32) 5 (3, 32) 5 (3, 32) 5 (3, 32)
n 15 (11, 49) 2 (1, 6) 7 (4, 18) 4 (1, 10) 0 (0, 5) 0 (0, 4) 0 (0, 3) 0 (0, 5) 2 (0, 8) 1 (0, 7) 1 (0, 4) 1 (0, 4) 0 (0, 5) 0 (0, 5) 0 (0, 4) 0 (0, 6)
post_p 0.28 (0.11, 0.47) 0.43 (0.29, 0.49) 0.36 (0.27, 0.46) 0.42 (0.14, 0.49) 0.41 (0.24, 0.48) 0.34 (0.19, 0.43) 0.38 (0.25, 0.46) 0.21 (0.14, 0.36) 0.29 (0.19, 0.46) 0.34 (0.19, 0.5) 0.42 (0.18, 0.46) 0.4 (0.18, 0.48) 0.28 (0.18, 0.43) 0.38 (0.24, 0.48) 0.42 (0.24, 0.46) 0.33 (0.2, 0.39)
r_prob 0.44 (0.44, 0.44) 0.35 (0.35, 0.35) 0.33 (0.33, 0.33) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.18 (0.18, 0.18) 0.18 (0.18, 0.18) 0.12 (0.12, 0.12) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.15 (0.098, 0.204) 0.17 (0, 0.364) 0.161 (0.119, 0.32) 0.151 (0.022, 0.429) 0.216 (0.144, 0.685) 0.293 (0.112, 0.378) 0.177 (0, 1.416) 0.212 (0.081, 0.492) 0.182 (0, 0.717) 0.048 (0, 0.172) 0.218 (0, 0.573) 0.236 (0.057, 0.754) 0.179 (0.059, 0.466) 0.147 (0.043, 0.195) 0.231 (0.058, 0.462) 0.219 (0.063, 0.49)
Carboplatin count 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6
time 27 (10, 34) 27 (10, 34) 27 (10, 34) 27 (10, 34) 27 (10, 34) 27 (10, 34) 27 (10, 34) 27 (10, 34) 27 (10, 34) 27 (10, 34) 27 (10, 34) 27 (10, 34) 27 (10, 34) 27 (10, 34) 27 (10, 34) 27 (10, 34)
n 14 (6, 34) 6 (1, 14) 12 (2, 26) 4 (2, 11) 4 (2, 11) 6 (2, 13) 4 (2, 7) 4 (1, 7) 4 (2, 14) 4 (2, 12) 3 (0, 8) 4 (2, 8) 3 (0, 10) 4 (2, 10) 2 (2, 4) 2 (2, 12)
post_p 0.38 (0.31, 0.44) 0.29 (0.22, 0.4) 0.19 (0.11, 0.39) 0.29 (0.13, 0.42) 0.33 (0.24, 0.42) 0.33 (0.16, 0.4) 0.35 (0.25, 0.48) 0.38 (0.15, 0.47) 0.39 (0.26, 0.47) 0.26 (0.13, 0.46) 0.27 (0.21, 0.45) 0.34 (0.2, 0.37) 0.16 (0.13, 0.46) 0.4 (0.24, 0.44) 0.41 (0.38, 0.48) 0.36 (0.21, 0.46)
r_prob 0 (0, 0) 0 (0, 0) 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.136 (0.126, 0.184) 0.141 (0.103, 0.318) 0.148 (0.128, 0.917) 0.114 (0.101, 1.36) 0.149 (0.112, 0.504) 0.184 (0.113, 0.384) 0.145 (0.117, 0.206) 0.183 (0.117, 2.268) 0.143 (0.121, 0.197) 0.124 (0.055, 0.168) 0.182 (0.071, 0.213) 0.203 (0.096, 0.261) 0.492 (0.111, 1.028) 0.152 (0.081, 0.303) 0.186 (0.089, 0.687) 0.121 (0.092, 0.245)
Niraparib count 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4
time 28 (22, 30) 28 (22, 30) 28 (22, 30) 28 (22, 30) 28 (22, 30) 28 (22, 30) 28 (22, 30) 28 (22, 30) 28 (22, 30) 28 (22, 30) 28 (22, 30) 28 (22, 30) 28 (22, 30) 28 (22, 30) 28 (22, 30) 28 (22, 30)
n 15 (8, 33) 4 (3, 6) 18 (11, 24) 6 (4, 11) 10 (4, 15) 4 (3, 9) 3 (2, 5) 3 (0, 6) 4 (1, 8) 4 (3, 7) 6 (4, 7) 5 (3, 8) 1 (0, 5) 2 (1, 4) 4 (3, 5) 4 (4, 5)
post_p 0.27 (0.09, 0.38) 0.37 (0.21, 0.45) 0.29 (0.16, 0.44) 0.33 (0.19, 0.48) 0.29 (0.22, 0.42) 0.33 (0.2, 0.43) 0.44 (0.4, 0.46) 0.31 (0.23, 0.35) 0.31 (0.24, 0.38) 0.22 (0.14, 0.29) 0.43 (0.37, 0.47) 0.29 (0.17, 0.39) 0.23 (0.17, 0.29) 0.38 (0.35, 0.46) 0.37 (0.35, 0.45) 0.24 (0.12, 0.36)
r_prob 0 (0, 0) 0 (0, 0) 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.138 (0.12, 0.32) 0.111 (0.081, 0.143) 0.137 (0.108, 0.17) 0.128 (0.08, 0.162) 0.163 (0.142, 0.459) 0.138 (0.087, 0.195) 0.144 (0.107, 0.163) 0.108 (0.101, 0.365) 0.159 (0.152, 0.179) 0.224 (0.15, 0.564) 0.144 (0.111, 0.176) 0.118 (0.081, 0.214) 0.263 (0.167, 0.359) 0.151 (0.067, 0.306) 0.201 (0.141, 0.212) 0.207 (0.126, 0.292)
TP53- & AR- Hormone_therapies count 244 244 244 244
time 19 (9, 32) 19 (9, 32) 19 (9, 32) 19 (9, 32)
n 26 (16, 72) 5 (2, 11) 4 (0, 10) 4 (1, 12)
post_p 0.32 (0.12, 0.47) 0.36 (0.18, 0.48) 0.4 (0.23, 0.48) 0.39 (0.18, 0.47)
r_prob 0.44 (0.44, 0.44) 0.35 (0.35, 0.35) 0 (0, 0) 0 (0, 0)
rate 0.127 (0.105, 0.166) 0.127 (0.075, 0.281) 0.175 (0.107, 0.569) 0.15 (0.082, 0.477)
Taxel_therapies count 6 6 6 6
time 22 (14, 31) 22 (14, 31) 22 (14, 31) 22 (14, 31)
n 18 (12, 64) 6 (2, 9) 4 (2, 12) 4 (0, 9)
post_p 0.22 (0.08, 0.39) 0.36 (0.26, 0.42) 0.42 (0.32, 0.48) 0.46 (0.37, 0.48)
r_prob 0.11 (0.11, 0.11) 0.29 (0.29, 0.29) 0 (0, 0) 0 (0, 0)
rate 0.129 (0.114, 0.178) 0.099 (0.071, 0.124) 0.15 (0.084, 0.382) 0.091 (0.073, 0.272)
Carboplatin count 221 221 221 221
time 21 (14, 32) 21 (14, 32) 21 (14, 32) 21 (14, 32)
n 20 (9, 61) 5 (2, 11) 6 (3, 13) 6 (3, 14)
post_p 0.37 (0.1, 0.48) 0.36 (0.17, 0.47) 0.38 (0.19, 0.49) 0.31 (0.12, 0.47)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.126 (0.104, 0.195) 0.139 (0.08, 0.401) 0.155 (0.107, 0.305) 0.126 (0.082, 0.282)
Niraparib count 208 208 208 208
time 22 (13, 33) 22 (13, 33) 22 (13, 33) 22 (13, 33)
n 20 (9, 63) 4 (2, 11) 6 (3, 13) 6 (3, 11)
post_p 0.37 (0.11, 0.48) 0.35 (0.17, 0.47) 0.38 (0.18, 0.48) 0.32 (0.13, 0.46)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.128 (0.105, 0.201) 0.138 (0.084, 0.467) 0.153 (0.101, 0.301) 0.13 (0.086, 0.259)
TP53+ Hormone_therapies count 74 74 74 74 74 74 74 74
time 25 (13, 33) 25 (13, 33) 25 (13, 33) 25 (13, 33) 25 (13, 33) 25 (13, 33) 25 (13, 33) 25 (13, 33)
n 16 (8, 35) 9 (4, 19) 3 (1, 8) 3 (1, 7) 4 (2, 9) 4 (2, 10) 3 (1, 6) 3 (1, 8)
post_p 0.35 (0.15, 0.47) 0.27 (0.1, 0.43) 0.39 (0.27, 0.48) 0.34 (0.2, 0.49) 0.38 (0.19, 0.48) 0.3 (0.15, 0.45) 0.41 (0.2, 0.48) 0.38 (0.21, 0.47)
r_prob 0.33 (0.33, 0.33) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0.12 (0.12, 0.12) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0)
rate 0.129 (0.104, 0.18) 0.119 (0.088, 0.185) 0.171 (0.109, 0.727) 0.175 (0.088, 0.802) 0.163 (0.099, 0.476) 0.171 (0.093, 0.382) 0.179 (0.117, 0.834) 0.143 (0.078, 0.494)
Taxel_therapies count 1 1 1 1 1 1 1 1
time 11 (11, 11) 11 (11, 11) 11 (11, 11) 11 (11, 11) 11 (11, 11) 11 (11, 11) 11 (11, 11) 11 (11, 11)
n 8 (8, 8) 8 (8, 8) 2 (2, 2) 1 (1, 1) 2 (2, 2) 2 (2, 2) 3 (3, 3) 2 (2, 2)
post_p 0.48 (0.48, 0.48) 0.29 (0.29, 0.29) 0.48 (0.48, 0.48) 0.41 (0.41, 0.41) 0.48 (0.48, 0.48) 0.46 (0.46, 0.46) 0.48 (0.48, 0.48) 0.43 (0.43, 0.43)
r_prob 0.17 (0.17, 0.17) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0) 0.37 (0.37, 0.37) 0.37 (0.37, 0.37) 0 (0, 0) 0 (0, 0)
rate 0.155 (0.155, 0.155) 0.117 (0.117, 0.117) 0.174 (0.174, 0.174) 1.509 (1.509, 1.509) 0.106 (0.106, 0.106) 0.375 (0.375, 0.375) 0.081 (0.081, 0.081) 0.106 (0.106, 0.106)
Carboplatin count 79 79 79 79 79 79 79 79
time 23 (13, 32) 23 (13, 32) 23 (13, 32) 23 (13, 32) 23 (13, 32) 23 (13, 32) 23 (13, 32) 23 (13, 32)
n 13 (7, 33) 7 (3, 18) 4 (2, 6) 3 (1, 8) 4 (1, 9) 4 (1, 9) 4 (2, 6) 4 (2, 7)
post_p 0.35 (0.15, 0.46) 0.3 (0.11, 0.47) 0.36 (0.19, 0.47) 0.4 (0.22, 0.48) 0.38 (0.21, 0.48) 0.35 (0.19, 0.47) 0.43 (0.24, 0.48) 0.38 (0.19, 0.48)
r_prob 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.138 (0.109, 0.225) 0.12 (0.083, 0.272) 0.184 (0.104, 0.52) 0.158 (0.085, 0.341) 0.182 (0.104, 0.513) 0.156 (0.085, 0.429) 0.156 (0.098, 0.547) 0.122 (0.075, 0.337)
Niraparib count 77 77 77 77 77 77 77 77
time 23 (13, 34) 23 (13, 34) 23 (13, 34) 23 (13, 34) 23 (13, 34) 23 (13, 34) 23 (13, 34) 23 (13, 34)
n 12 (6, 29) 7 (3, 18) 3 (2, 6) 4 (1, 8) 4 (2, 9) 4 (1, 10) 5 (2, 8) 3 (1, 6)
post_p 0.3 (0.12, 0.48) 0.29 (0.11, 0.46) 0.4 (0.25, 0.49) 0.36 (0.15, 0.47) 0.41 (0.21, 0.48) 0.35 (0.17, 0.48) 0.4 (0.27, 0.48) 0.36 (0.17, 0.48)
r_prob 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.137 (0.102, 0.282) 0.127 (0.079, 0.331) 0.177 (0.087, 0.379) 0.129 (0.074, 0.304) 0.171 (0.096, 0.327) 0.147 (0.082, 0.497) 0.153 (0.097, 0.285) 0.166 (0.09, 0.54)
DRD+ Hormone_therapies count 41 41 41 41 41 41 41 41
time 28 (19, 35) 28 (19, 35) 28 (19, 35) 28 (19, 35) 28 (19, 35) 28 (19, 35) 28 (19, 35) 28 (19, 35)
n 5 (1, 13) 4 (1, 14) 3 (1, 6) 4 (1, 7) 3 (1, 7) 4 (1, 11) 3 (1, 6) 4 (2, 7)
post_p 0.37 (0.22, 0.46) 0.34 (0.13, 0.48) 0.4 (0.23, 0.48) 0.34 (0.18, 0.47) 0.36 (0.19, 0.48) 0.37 (0.17, 0.48) 0.36 (0.19, 0.48) 0.34 (0.18, 0.44)
r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.173 (0.105, 0.493) 0.153 (0.071, 0.705) 0.179 (0.123, 0.514) 0.15 (0.089, 0.719) 0.18 (0.09, 0.423) 0.138 (0.087, 0.398) 0.188 (0.113, 0.444) 0.184 (0.097, 0.423)
Taxel_therapies count 2 2 2 2 2 2 2 2
time 24 (19, 28) 24 (19, 28) 24 (19, 28) 24 (19, 28) 24 (19, 28) 24 (19, 28) 24 (19, 28) 24 (19, 28)
n 6 (4, 7) 6 (4, 9) 4 (2, 6) 1 (0, 2) 2 (1, 4) 0 (0, 1) 4 (3, 6) 2 (2, 2)
post_p 0.31 (0.27, 0.35) 0.45 (0.41, 0.48) 0.23 (0.08, 0.38) 0.44 (0.44, 0.44) 0.43 (0.38, 0.48) 0.48 (0.48, 0.48) 0.34 (0.26, 0.42) 0.42 (0.4, 0.45)
r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.206 (0.166, 0.245) 0.093 (0.084, 0.101) 0.384 (0.343, 0.425) 0.189 (0.189, 0.189) 0.303 (0.176, 0.43) 0.143 (0.143, 0.143) 0.23 (0.21, 0.25) 0.113 (0.113, 0.113)
Carboplatin count 81 81 81 81 81 81 81 81
time 22 (14, 31) 22 (14, 31) 22 (14, 31) 22 (14, 31) 22 (14, 31) 22 (14, 31) 22 (14, 31) 22 (14, 31)
n 6 (2, 11) 5 (3, 11) 4 (1, 7) 4 (2, 6) 4 (1, 8) 4 (1, 6) 3 (1, 7) 4 (2, 7)
post_p 0.36 (0.17, 0.49) 0.3 (0.1, 0.44) 0.38 (0.2, 0.48) 0.37 (0.21, 0.48) 0.42 (0.27, 0.48) 0.37 (0.17, 0.48) 0.4 (0.23, 0.49) 0.37 (0.19, 0.48)
r_prob 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.152 (0.096, 0.287) 0.145 (0.082, 0.443) 0.166 (0.093, 0.401) 0.15 (0.072, 0.37) 0.143 (0.09, 0.312) 0.15 (0.085, 0.444) 0.156 (0.093, 0.465) 0.136 (0.077, 0.349)
Niraparib count 67 67 67 67 67 67 67 67
time 20 (14, 32) 20 (14, 32) 20 (14, 32) 20 (14, 32) 20 (14, 32) 20 (14, 32) 20 (14, 32) 20 (14, 32)
n 6 (3, 13) 5 (3, 11) 4 (2, 7) 4 (1, 8) 3 (1, 6) 4 (2, 7) 4 (2, 7) 3 (1, 7)
post_p 0.37 (0.19, 0.48) 0.34 (0.15, 0.47) 0.41 (0.32, 0.49) 0.34 (0.18, 0.49) 0.39 (0.2, 0.48) 0.36 (0.21, 0.46) 0.37 (0.21, 0.47) 0.37 (0.19, 0.48)
r_prob 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.141 (0.098, 0.256) 0.134 (0.08, 0.276) 0.165 (0.091, 0.376) 0.148 (0.072, 0.35) 0.177 (0.105, 0.853) 0.148 (0.078, 0.342) 0.171 (0.117, 0.375) 0.163 (0.085, 0.301)
TEfus+ Hormone_therapies count 218 218 218 218 218 218 218 218
time 26 (16, 35) 26 (16, 35) 26 (16, 35) 26 (16, 35) 26 (16, 35) 26 (16, 35) 26 (16, 35) 26 (16, 35)
n 6 (3, 12) 9 (5, 23) 5 (1, 15) 4 (1, 8) 4 (2, 9) 4 (2, 9) 4 (1, 9) 3 (1, 9)
post_p 0.29 (0.12, 0.46) 0.24 (0.08, 0.45) 0.35 (0.15, 0.47) 0.38 (0.22, 0.47) 0.34 (0.16, 0.47) 0.31 (0.16, 0.46) 0.39 (0.18, 0.48) 0.38 (0.19, 0.48)
r_prob 0.35 (0.35, 0.35) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0.18 (0.18, 0.18) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0)
rate 0.13 (0.086, 0.284) 0.12 (0.083, 0.22) 0.138 (0.077, 0.335) 0.152 (0.087, 0.545) 0.139 (0.079, 0.342) 0.148 (0.085, 0.344) 0.141 (0.088, 0.367) 0.153 (0.083, 0.458)
Carboplatin count 239 239 239 239 239 239 239 239
time 26 (16, 34) 26 (16, 34) 26 (16, 34) 26 (16, 34) 26 (16, 34) 26 (16, 34) 26 (16, 34) 26 (16, 34)
n 5 (2, 12) 8 (3, 22) 6 (3, 15) 4 (2, 8) 4 (2, 11) 4 (2, 10) 4 (2, 8) 4 (2, 8)
post_p 0.36 (0.16, 0.47) 0.25 (0.08, 0.45) 0.3 (0.11, 0.47) 0.35 (0.18, 0.48) 0.38 (0.17, 0.48) 0.33 (0.18, 0.48) 0.37 (0.2, 0.47) 0.38 (0.18, 0.48)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.136 (0.082, 0.337) 0.126 (0.086, 0.249) 0.13 (0.079, 0.34) 0.149 (0.083, 0.381) 0.137 (0.083, 0.382) 0.14 (0.08, 0.319) 0.138 (0.08, 0.35) 0.133 (0.078, 0.338)
Niraparib count 227 227 227 227 227 227 227 227
time 26 (17, 35) 26 (17, 35) 26 (17, 35) 26 (17, 35) 26 (17, 35) 26 (17, 35) 26 (17, 35) 26 (17, 35)
n 5 (2, 12) 8 (4, 25) 6 (3, 14) 4 (2, 9) 5 (2, 10) 5 (2, 12) 4 (2, 9) 4 (2, 8)
post_p 0.33 (0.14, 0.47) 0.25 (0.08, 0.45) 0.29 (0.12, 0.47) 0.35 (0.18, 0.49) 0.35 (0.16, 0.48) 0.33 (0.17, 0.46) 0.36 (0.2, 0.47) 0.34 (0.14, 0.46)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.138 (0.08, 0.378) 0.123 (0.086, 0.233) 0.127 (0.081, 0.247) 0.129 (0.077, 0.356) 0.134 (0.078, 0.371) 0.133 (0.083, 0.429) 0.132 (0.089, 0.312) 0.147 (0.08, 0.336)